RESUMEN

The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.

Asunto(s)

Finasterida/química , Polímeros/química , beta-Ciclodextrinas/química , 2-Hidroxipropil-beta-Ciclodextrina , Rastreo Diferencial de Calorimetría , Quitosano/química , Finasterida/síntesis química , Liofilización , Espectroscopía de Resonancia Magnética , Povidona/química , Solubilidad , Difracción de Rayos X , beta-Ciclodextrinas/síntesis química