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1.
Mem Inst Oswaldo Cruz ; 113(9): e180051, 2018 Jul 10.
Artículo en Inglés | MEDLINE | ID: mdl-29995109

RESUMEN

Multidrug-resistant (MDR) Corynebacterium striatum has been cited with increased frequency as pathogen of nosocomial infections. In this study, we report the draft genome of a C. striatum isolated from a patient with bloodstream infection in a hospital of Rio de Janeiro, Brazil. The isolate presented susceptibility only to tetracycline, vancomycin and linezolid. The detection of various antibiotic resistance genes is fully consistent with previously observed multidrug-resistant pattern in Corynebacterium spp. A large part of the pTP10 plasmid of MDR C. striatum M82B is present in the genome of our isolate. A SpaDEF cluster and seven arrays of CRISPR-Cas were found.


Asunto(s)
Bacteriemia/microbiología , Infecciones por Corynebacterium/microbiología , Corynebacterium/efectos de los fármacos , Corynebacterium/genética , Infección Hospitalaria/microbiología , Farmacorresistencia Bacteriana Múltiple/genética , Genoma Bacteriano/genética , Antibacterianos/farmacología , Brasil , Corynebacterium/aislamiento & purificación , Brotes de Enfermedades , Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos , Electroforesis en Gel de Campo Pulsado , Genotipo , Humanos , Pruebas de Sensibilidad Microbiana , Análisis de Secuencia de ADN
2.
Mem. Inst. Oswaldo Cruz ; 113(9): e180051, 2018. graf
Artículo en Inglés | LILACS | ID: biblio-955124

RESUMEN

Multidrug-resistant (MDR) Corynebacterium striatum has been cited with increased frequency as pathogen of nosocomial infections. In this study, we report the draft genome of a C. striatum isolated from a patient with bloodstream infection in a hospital of Rio de Janeiro, Brazil. The isolate presented susceptibility only to tetracycline, vancomycin and linezolid. The detection of various antibiotic resistance genes is fully consistent with previously observed multidrug-resistant pattern in Corynebacterium spp. A large part of the pTP10 plasmid of MDR C. striatum M82B is present in the genome of our isolate. A SpaDEF cluster and seven arrays of CRISPR-Cas were found.


Asunto(s)
Humanos , Infección Hospitalaria/transmisión , Genoma/genética , Infecciones por Corynebacterium/terapia , Brasil/epidemiología
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