RESUMEN
Intravascular papillary endothelial hyperplasia (IPEH) is characterized by proliferation of endothelial cells usually occurring within a long-standing vascular malformation or tumor. IPEH usually affects neck, head and lower extremities, and few orbital and eyelid cases have been reported. We present a unique case, a 48-years-old man with a purple, elevated, multilobular conjunctival lesion of three-weeks duration that underwent an excisional biopsy. Pathological features revealed intravascular papillary endothelial hyperplasia (Masson's tumor).
Asunto(s)
Neoplasias Vasculares , Conjuntiva/patología , Células Endoteliales/patología , Párpados/patología , Humanos , Hiperplasia/patología , Masculino , Persona de Mediana Edad , Neoplasias Vasculares/patologíaRESUMEN
OBJECTIVE: To describe the ultrasound, histopathological and genetic characteristics of uveal melanoma in a Mexican-Mestizo population. MATERIAL AND METHODS: A total of 39 enucleated eyes with a histopathological diagnosis of uveal melanoma were assessed by describing the clinical findings, and ultrasound, histopathological and genetic features. RESULTS: A high correlation was observed between tumour height measurement using ultrasound and histopathology. In our cases, tumour size and reflectivity were higher compared with those reported in the literature. The preliminary data on the molecular assessment of the tumours show the presence of an unreported polymorphism (T>C IVS5+34) and one sample with GNAQ mutation (A>C CAA>CCA Gln 209 Pro). CONCLUSION: Ultrasound is a reliable method to identify the size of the tumour. Furthermore, knowledge of the molecular mechanisms promises new perspectives for the development of new targeted therapeutics. Fortunately this leads to progress in the treatment of patients with metastatic disease or prevents it in those at high risk.
Asunto(s)
Melanoma/diagnóstico , Melanoma/genética , Neoplasias de la Úvea/diagnóstico , Neoplasias de la Úvea/genética , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Estudios Transversales , Femenino , Humanos , Masculino , Melanoma/diagnóstico por imagen , Melanoma/patología , México , Persona de Mediana Edad , Grupos Raciales , Estudios Retrospectivos , Ultrasonografía , Neoplasias de la Úvea/diagnóstico por imagen , Neoplasias de la Úvea/patología , Adulto JovenRESUMEN
A 6-year-old girl presented with right divergent strabismus that had been noticed by her parents 3 weeks before. On examination, she had visual acuity of counting fingers at 3 meters on her right eye and retinal non-regmatogenous bullous detachment with subretinal tumor. Echographic examination disclosed retinal detachment in temporal side from optic disk to equator, a medium reflectivity rounded, homogeneous lesion with rapid growing and positive signs of vascularity. Enucleated eye revealed mixed cell uveal melanoma. This case is a rare presentation of uveal melanoma in which echographic appearance was decisive for diagnosis and treatment.
Asunto(s)
Neoplasias de la Coroides/diagnóstico por imagen , Melanoma/diagnóstico por imagen , Niño , Femenino , Humanos , UltrasonografíaRESUMEN
PURPOSE: To analyze the clinicopathologic characteristics of uveal melanoma in Mexican patients under thirty years old. METHODS: We reviewed the cases from the Service of Ophthalmic Pathology with histopathologic diagnosis of uveal melanoma from 1957 to March 2002. The data analyzed were: age, gender, affected eye, clinical diagnosis, size, cellular type, mitotic index, lymphocytic infiltrate, vascular pattern, necrosis, vascular and/or intraocular invasion and orbital extension. RESULTS: We reviewed 122 cases diagnosed with uveal melanoma, and 14 patients were younger than 30 years old (11.4%). The mean age was 21.7 years, with female preponderance. Preoperative clinical diagnoses were uveal melanoma in 92.8%, most of the cases originated from choroid. The most frequent cellular type was spindle cells and 3 and 4 Folberg's vascular patterns. CONCLUSIONS: Our results suggest that the clinicians should consider uveal melanoma more frequently as another differential diagnosis in patients under thirty years with an intraocular tumor. The histological characteristics found have been correlated with a better prognosis.