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Trop Anim Health Prod ; 55(6): 360, 2023 Oct 18.
Artículo en Inglés | MEDLINE | ID: mdl-37851183

RESUMEN

Poultry is commonly infected by different bacteria and parasites in the environment, resulting in increased morbidity and mortality, but immunostimulants have been enhancing non-specific defense mechanisms conferring laying hens' protection. For this purpose, the pulp of yellow (Pouteria campechiana), white (Casimiroa edulis), and black (Diospyros digyna) sapotes were nanoencapsulated (YWB-SN) and evaluated in laying hens' peripheral blood leukocytes to test their addition to the experimental diets at a concentration of 0.5% (5g/kg of dry food) for 1 month (with two samples at days 15 and 30). The YWB-SN were safe when exposed to peripheral blood leukocytes (PBLs). The in vitro experiment showed that these nanocapsules enhanced reactive oxygen species production, and B-SN stimulated phagocytosis activity. Concerning the proinflammatory cytokine (TNF-α) transcription, this gene was upregulated after W-SN stimulation, while B-SN upregulated the IgG gene expression significantly. IgM was upregulated with any YBW-SN in PBLs after 24 h of stimulation. The in vivo study showed a notable B-SN immunostimulation in serum and an upregulation of TNF-α, IgM, and IgG mRNA transcription. Therefore, this study provides a new result of the yellow, white, and black sapote nanocapsules as a functional food for the poultry industry, highlighting the black sapote Diospyros digyna immunostimulant effect.


Asunto(s)
Casimiroa , Diospyros , Manilkara , Nanocápsulas , Pouteria , Animales , Femenino , Pollos/fisiología , Adyuvantes Inmunológicos/farmacología , Factor de Necrosis Tumoral alfa , Dieta/veterinaria , Aves de Corral , Suplementos Dietéticos , Inmunoglobulina G , Inmunoglobulina M , Alimentación Animal/análisis
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