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Environ Toxicol Pharmacol ; 34(3): 969-76, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22974793

RESUMEN

In the present study, the polycyclic aromatic hydrocarbon (PAH) genotoxicity was investigated in a one-step predator-prey relationship with the trophic-related marine species. Florida pompanos were fed for 5 and 10 days with pink shrimp post larvae previously exposed to benzo(a)pyrene (BaP) concentrations. Parent BaP body burden was measured in samples of Farfantepenaeus brasiliensis. BaP metabolites were determined in bile samples of Trachinotus carolinus and DNA damage was assessed through the comet and erythrocyte nuclear abnormalities (ENAs) assays in fish erythrocytes. BaP body burden increased significantly with the PAH concentration in pink shrimp PLs as well as the fish bile BaP metabolites. Both, comet and ENAs assays indicated significant increase on erythrocyte DNA damage of Florida pompanos fed with BaP-exposed pink shrimp on both feeding periods. The trophic route of BaP genotoxicity is discussed as well as the PAH biotransformation as the inducing mechanism for the DNA damages observed.


Asunto(s)
Benzo(a)pireno/toxicidad , Cadena Alimentaria , Mutágenos/toxicidad , Contaminantes Químicos del Agua/toxicidad , Animales , Daño del ADN , Relación Dosis-Respuesta a Droga , Larva , Penaeidae , Perciformes
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