RESUMEN
We compared the rates of elimination of sevoflurane and halothane in 29 children, aged between one and seven years, undergoing ambulatory anaesthesia. Analgesia was provided by fentanyl and muscle relaxation by atracurium. Anaesthesia was maintained by inhalation of one MAC of either sevoflurane or halothane, based on an equipotent concentration of each agent for the age of the child. Following simultaneous discontinuation of N2O and the inhalational agent, the equation describing N2O washout was identical in the presence of halothane and sevoflurane, showing that there was no effect of the volatile agent on the rate of N2O elimination. The elimination of sevoflurane and N2O give similar types of equations. Halothane elimination gives a logarithmic type of equation, showing a slower release, corresponding to residual tissue content.
Asunto(s)
Anestésicos por Inhalación/farmacocinética , Éteres/farmacocinética , Éteres Metílicos , Procedimientos Quirúrgicos Ambulatorios , Analgesia , Analgésicos Opioides/administración & dosificación , Anestésicos por Inhalación/administración & dosificación , Atracurio/administración & dosificación , Niño , Preescolar , Éteres/administración & dosificación , Fentanilo/administración & dosificación , Halotano/administración & dosificación , Halotano/farmacocinética , Humanos , Lactante , Cinética , Modelos Lineales , Fármacos Neuromusculares no Despolarizantes/administración & dosificación , Óxido Nitroso/administración & dosificación , Óxido Nitroso/farmacocinética , Alveolos Pulmonares/metabolismo , Respiración , Sevoflurano , Factores de TiempoAsunto(s)
Anestesia por Inhalación , Artrogriposis/cirugía , Halotano , Máscaras Laríngeas , Preescolar , HumanosAsunto(s)
Anestesiología/instrumentación , Intubación Intratraqueal , Laringe , Máscaras , Femenino , Humanos , Persona de Mediana EdadRESUMEN
HCl-demineralized mid-diaphyseal allogeneic segments of tibia were implanted in the lumbar muscles of rats fed either a magnesium-deficient or a magnesium-supplemented diet for one week prior to implantation and for three weeks thereafter. Histological studies, histochemical mucopolysaccharide determinations, tests for protease content of undemineralized bone tissue, and microradiography showed that in the normal hosts mostly trabecular bone grew into the heterotopic site, whereas in the deficient rats a large fibrous covering formed about the implant and in many instances cartilage was present in multiple locations under the fibrous coat. In some instances cartilage wedges, not preceded by multinucleated giant cells (matrixclasts), invaded the implant. This fibrocartilaginous response to an exogenous inductor resembled the modified growth pattern of bone recently reported in magnesium-deficient rats.