1.
J Org Chem
; 86(17): 12436-12442, 2021 09 03.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34399579
RESUMEN
Methods that functionalize the periphery of azacylic scaffolds have garnered increasing interest in recent years. Herein, we investigate the selectivity of a solid-state Norrish-Yang cyclization (NYC) and subsequent C-C cleavage/cross-coupling reaction of a strained cyclopropane-fused azacyclic system. Surprisingly, the NYC primarily furnished a single lactam constitutional and diastereo-isomer. The regioselectivity of the C-C cleavage of the α-hydroxy-ß-lactam moiety could be varied by altering the ligand set used in the coupling chemistry. Experimental and computational observations are discussed.