RESUMEN
Breast cancer (BRCA) is a serious public health problem, as it is the most frequent malignant tumor in women worldwide. BRCA is a molecularly heterogeneous disease, particularly at gene expression (mRNAs) level. Recent evidence shows that coding RNAs represent only 34% of the total transcriptome in a human cell. The rest of the 66% of RNAs are non-coding, so we might be missing relevant biological, clinical or regulatory information. In this report, we identified two novel tumor types from TCGA with LINC00460 deregulation. We used survival analysis to demonstrate that LINC00460 expression is a marker for poor overall (OS), relapse-free (RFS) and distant metastasis-free survival (DMFS) in basal-like BRCA patients. LINC00460 expression is a potential marker for aggressive phenotypes in distinct tumors, including HPV-negative HNSC, stage IV KIRC, locally advanced lung cancer and basal-like BRCA. We show that the LINC00460 prognostic expression effect is tissue-specific, since its upregulation can predict poor OS in some tumors, but also predicts an improved clinical course in BRCA patients. We found that the LINC00460 expression is significantly enriched in the Basal-like 2 (BL2) TNBC subtype and potentially regulates the WNT differentiation pathway. LINC00460 can also modulate a plethora of immunogenic related genes in BRCA, such as SFRP5, FOSL1, IFNK, CSF2, DUSP7 and IL1A and interacts with miR-103-a-1, in-silico, which, in turn, can no longer target WNT7A. Finally, LINC00460:WNT7A ratio constitutes a composite marker for decreased OS and DMFS in Basal-like BRCA, and can predict anthracycline therapy response in ER-BRCA patients. This evidence confirms that LINC00460 is a master regulator in BRCA molecular circuits and influences clinical outcome.
RESUMEN
Sebaceous glands typically are located in the pilosebaceous unit located in the superficial layers of the skin. Thus, ectopic sebaceous glands in the esophagus are a very unusual condition. Since 1962 when De la Pava and Pickren described that sebaceous glands could be ectopically located in the esophagus, no more than 30 cases have been reported in the literature. Macroscopically, single or multiple nodular yellowish lesions are found, and most of the times are overlooked. In this paper, we describe 3 cases (2 female and one male) of ectopic sebaceous glands in the esophagus incidentally detected during routine upper gastrointestinal tract endoscopic examination. Histopathology diagnoses were supported using immunohistochemestry for AE1/AE3 citokeratins and epithelial membrane antigen.
Asunto(s)
Coristoma/patología , Enfermedades del Esófago/patología , Glándulas Sebáceas , Adulto , Anciano de 80 o más Años , Femenino , Humanos , Hallazgos Incidentales , Masculino , Persona de Mediana EdadRESUMEN
Resumen La presencia de glándulas sebáceas en el esófago constituye una entidad poco frecuente, debido a que estas normalmente se encuentran en la unidad pilosebácea de la piel. Macroscópicamente se observan como lesiones nodulares amarillentas, únicas o múltiples y que a veces pasan inadvertidas. En este trabajo describimos 3 casos (2 mujeres y un hombre) con localización ectópica de glándulas sebáceas en el esófago detectadas de forma incidental durante la realización de estudios endoscópicos del tracto digestivo superior. En todos los casos el diagnóstico histopatológico se confirmó mediante inmunohistoquímica para citoqueratinas AE1/AE3 y antígeno de membrana epitelial. (AU)
AbstractSebaceous glands typically are located in the pilosebaceous unit located in the superficial layers of the skin. Thus, ectopic sebaceous glands in the esophagus are a very unusual condition. Since 1962 when De la Pava and Pickren described that sebaceous glands could be ectopically located in the esophagus, no more than 30 cases have been reported in the literature. Macroscopically, single or multiple nodular yellowish lesions are found, and most of the times are overlooked. In this paper, we describe 3 cases (2 female and one male) of ectopic sebaceous glands in the esophagus incidentally detected during routine upper gastrointestinal tract endoscopic examination. Histopathology diagnoses were supported using immunohistochemestry for AE1/AE3 citokeratins and epithelial membrane antigen (AU)
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano de 80 o más Años , Coristoma/patología , Enfermedades del Esófago/patología , Hallazgos Incidentales , Glándulas SebáceasRESUMEN
El síndrome de movilidad articular limitada se presenta en 30 y 25 por ciento de los enfermos con diabetes mellitus tipo I y II, respectivamente; este síndrome no se diagnostica en forma adecuada y oportuna por el clínico. En su causa se han identificado alteraciones en el metabolismo de la colágena y se ha relacionado con las complicaciones micro y macrovasculares de la diabetes mellitus. La aparición temprana del síndrome de movilidad articular limitada en el paciente diabético es un factor predictivo de alto riesgo para el desarrollo de complicaciones tardías. En el caso que se reporta se describe el cuadro clínico, así como datos radiológicos e histopatológicos que integran este síndrome
Asunto(s)
Humanos , Femenino , Adulto , Articulación Metacarpofalángica/fisiopatología , Contractura/fisiopatología , Diabetes Mellitus/complicaciones , MovimientoRESUMEN
Se trata de una paciente femenina de 19 años de edad con antecedentes de hirsutismo desde la infancia, hiperpigmentación de la piel, cuadros frecuentes de candidiasis oral. Alérgica a la penicilina. Púrpura vascular idiopática desde los 15 años de edad, cara de luna llena y giba dorsal. Menarca a los 14 con amenorrea secundaria durante un año, se dio tratamiento con hormonales y al suspenderse presenta amenorrea nuevamente