Asunto(s)
Hiperpigmentación , Femenino , Humanos , Diagnóstico Diferencial , Extremidades , Hiperpigmentación/diagnóstico , Torso , AncianoRESUMEN
An x-ray revealed the source of the toe nodule and the nail dystrophy.
Asunto(s)
Enfermedades de la Uña , Fútbol , Humanos , Dolor/etiología , RadiografíaAsunto(s)
Fluorouracilo/administración & dosificación , Enfermedades de la Piel/etiología , Rayos Ultravioleta/efectos adversos , Deportes Acuáticos , Escamas de Animales/efectos de los fármacos , Animales , Fluorouracilo/uso terapéutico , Humanos , Inmunosupresores/administración & dosificación , Inmunosupresores/uso terapéutico , Masculino , Persona de Mediana Edad , Enfermedades de la Piel/diagnóstico , Enfermedades de la Piel/tratamiento farmacológicoRESUMEN
We describe a patient with subclinical coccidioidomycosis who experienced rapid disease dissemination shortly after SARS-CoV-2 infection, suggesting host immune response dysregulation to coccidioidomycosis by SARS-CoV-2. We hypothesize that disrupted cell-mediated signaling may result after SARS-CoV-2 infection leading to functional exhaustion and CD8+ T-cell senescence with impairment in host cellular response to Coccidioides infection.
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COVID-19 , Coccidioidomicosis , Coccidioides , Coccidioidomicosis/complicaciones , Coccidioidomicosis/diagnóstico , Humanos , SARS-CoV-2Asunto(s)
Dermatofibrosarcoma/diagnóstico , Recurrencia Local de Neoplasia/diagnóstico , Neoplasias Cutáneas/diagnóstico , Muslo , Anciano , Dermatofibrosarcoma/patología , Dermatofibrosarcoma/cirugía , Diagnóstico Diferencial , Humanos , Masculino , Cirugía de Mohs , Recurrencia Local de Neoplasia/patología , Recurrencia Local de Neoplasia/cirugía , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/cirugíaRESUMEN
BACKGROUND Epidermolysis bullosa acquisita is a rare, subepithelial bullous disorder, which is distinguished from other autoimmune blistering diseases by the production of antibodies against type VII collagen. CASE REPORT Here, we describe the case of a 79-year-old male resident of the Northern Mariana Islands who presented to the clinic with multiple blistering skin lesions. CONCLUSIONS The primary focus of treatment is to prevent disease progression and serious complications of scarring (including blindness and respiratory obstruction) by avoiding physical trauma and suppressing the immune systems with agents, including corticosteroids, colchicine, dapsone, methotrexate, and cyclophosphamide. Successful treatment of the condition should involve a multidisciplinary team of medical professionals with regular monthly follow-ups during periods of active disease.
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Enfermedades Autoinmunes/diagnóstico , Epidermólisis Ampollosa Adquirida/diagnóstico , Absceso/terapia , Anciano , Antiinflamatorios/uso terapéutico , Enfermedades Autoinmunes/tratamiento farmacológico , Colágeno Tipo VII/inmunología , Epidermólisis Ampollosa Adquirida/complicaciones , Epidermólisis Ampollosa Adquirida/tratamiento farmacológico , Humanos , Masculino , Micronesia , Prednisona/uso terapéutico , Infecciones Estafilocócicas/terapiaRESUMEN
The initial livedo skin changes of cutis marmorata, also known as cutaneous decompression sickness (DCS), are transient in nature. Accordingly, early images of violaceous skin changes with variegated, marbled, or mottled appearance are rare, whereas later images of deep, erythematous, or violaceous skin changes are readily available. This case presents the opportunity to view the early skin changes characteristic of cutaneous DCS, which would likely manifest at Level I care in the setting of a diving injury during Special Operations missions in austere environments. The unique diving context also allows an overview of DCS in addition to a review of skin eruptions associated with various marine life. As diving is frequently used by Naval Special Warfare, topics presented in this case have significant relevance to Special Operations.
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Enfermedad de Descompresión/diagnóstico , Buceo/efectos adversos , Enfermedades Cutáneas Vasculares/diagnóstico , Exantema , Humanos , Personal MilitarRESUMEN
We report a case of Endemic African Cutaneous Kaposi Sarcoma (EACKS) on the lower extremity of an immunocompetent 31-yr-old male service member from Cameroon. Diagnosis was made using clinical and histologic findings. The service member was treated with local radiation therapy with resolution of his tumor.The goal of this article is to educate practitioners to counsel susceptible service members and leadership on the risk of developing EACKS when traveling to Sub-Saharan Africa, monitor for disease development, and guide in the diagnosis and treatment of patients with this rare disease.
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Consejo/métodos , Educación en Salud/métodos , Personal Militar , Sarcoma de Kaposi/diagnóstico , Adulto , Camerún , Consejo/normas , Educación en Salud/normas , Humanos , Masculino , Sarcoma de Kaposi/fisiopatología , Piel/patología , Neoplasias Cutáneas/complicacionesAsunto(s)
Analgésicos/efectos adversos , Quemaduras/etiología , Calor/efectos adversos , Salicilatos/efectos adversos , Administración Cutánea , Analgésicos/administración & dosificación , Femenino , Humanos , Persona de Mediana Edad , Dolor Musculoesquelético/terapia , Medicamentos sin Prescripción/administración & dosificación , Medicamentos sin Prescripción/efectos adversos , Salicilatos/administración & dosificaciónRESUMEN
Dyskeratosis congenita (DC) is a rare, inherited, bone marrow failure syndrome caused by premature telomere shortening. The classic mucocutaneous triad of clinical features comprises reticulated skin pigmentation, nail dysplasia, and oral leukoplakia. Multiple somatic features, including bone marrow failure, pulmonary fibrosis, and liver disease, are also common. DC significantly increases the risk for malignant transformation, including myelodysplastic syndrome, acute myeloid leukemia, head and neck squamous cell carcinoma, and anogenital cancer. This case report describes a 23-year-old female with malignant transformation of oral leukoplakia to squamous cell carcinoma, demonstrated in a series of biopsies of the same site. Increased surveillance, proper biopsy technique, and a multidisciplinary approach are critical for patients with DC to ensure rapid diagnosis and treatment.
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Carcinoma de Células Escamosas/patología , Transformación Celular Neoplásica/patología , Disqueratosis Congénita/patología , Leucoplasia Bucal/patología , Neoplasias de la Lengua/patología , Biopsia , Carcinoma de Células Escamosas/cirugía , Disqueratosis Congénita/cirugía , Femenino , Humanos , Leucoplasia Bucal/cirugía , Neoplasias de la Lengua/cirugía , Adulto JovenRESUMEN
Given that the majority of active duty service members are young and healthy, potentially malignant diagnoses such as skin cancer may be overlooked. Although melanoma accounts for only approximately 1% of skin cancers, it causes the greatest majority of skin cancer deaths. We present the case of a 27-year-old active duty Marine who presented with a hyperpigmented macule at his lateral neck that was a malignant melanoma in situ. This article reviews risk factors for the development of melanoma, offers guidelines for primary care providers, reviews resources for providers in a deployed or austere environment, offers recommendations for prevention and early diagnosis, and discusses follow up.
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Melanoma/diagnóstico , Personal Militar , Adulto , Detección Precoz del Cáncer/métodos , Humanos , Masculino , Tamizaje Masivo/métodos , Melanoma/prevención & control , Factores de RiesgoAsunto(s)
Ectima Contagioso/diagnóstico , Dermatosis de la Mano/diagnóstico , Adolescente , Carbunco/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Infecciones por Mycobacterium no Tuberculosas/diagnóstico , Nocardiosis/diagnóstico , Enfermedades Cutáneas Bacterianas/diagnóstico , Esporotricosis/diagnósticoRESUMEN
Tattoos are ubiquitous in modern society; however, they do not come without risk of medical complications. When complications arise in the military community, a particularly thorough differential diagnosis should be considered based on the increased exposures service members have during deployment and throughout their military career. We present a case of a 38-year-old active duty US Marine Corps woman with worsening skin lesions arising within a tattoo 6 weeks after acquiring the tattoo on her right chest. Given environmental exposures from a recent deployment to the Middle East, a wide differential was considered. Ultimately, a skin biopsy revealed early hypertrophic scar formation responsive to therapy with intralesional triamcinolone acetonide (Kenalog® [ILK]). However, given the Marine had recently deployed and is part of the active duty population, consideration of alternative, albeit rare, etiologies was imperative.