RESUMEN

Previous studies showed that mild iron deficiency anaemia (IDA) induced by feeding an iron deficient (ID) diet to female guinea pigs during gestation and lactation to alters the auditory functions of the offspring when corn oil is the only source of dietary lipids. Conversely, feeding an ID diet with a dietary fatty acid composition similar to that of typical human western diets induced minor impairments. Since tissue fatty acid metabolism is affected by dietary iron, the current study measured the impacts of these ID diets (ID-corn and ID-west) compared to the corresponding iron-sufficient control diets (IS-corn and IS-west) on encephalum fatty acid metabolism in the offspring at post-natal day 24. IDA induced by the ID-corn diet resulted in significant increases in encephalum n-6 PUFA content, but IDA induced by the ID-west diet had little impact on fatty acid profiles compared to the IS-west group. Brain COX II protein expression and FADS2 mRNA expression were statistically unaffected in both experiments, but encephalum PGE2 concentrations were significantly reduced in ID-west pups. These results suggest IDA studies during prenatal development should consider dietary lipid compositions.

Asunto(s)

Cerebro/metabolismo , Grasas de la Dieta , Eicosanoides/metabolismo , Deficiencias de Hierro , Hierro de la Dieta , Lactancia/sangre , Anemia Ferropénica/metabolismo , Animales , Animales Recién Nacidos , Dieta , Femenino , Cobayas , Hierro/sangre , Masculino , Fenómenos Fisiológicos de la Nutrición , Embarazo , Efectos Tardíos de la Exposición Prenatal

RESUMEN

OBJECTIVES: The aim of this study was to evaluate the hearing function in the guinea pig offspring at post-natal day (PNd) 24 and PNd84 born from dams suffering from iron deficiency during pregnancy and lactation by using the auditory brainstem response (ABR). METHOD: Female guinea pigs (n = 24 per dietary group) were fed an iron sufficient (IS) diet (114 mg/kg) or an iron deficient (ID) diet (11.7 mg/kg) during the gestation and lactation periods. Pups in both groups were weaned at PNd9 and given the IS diet. The hematocrit level was measured at every trimester of pregnancy and at the day of sacrifice in dams and at PNd24 and PNd84 in pups. The animal body weight was measured on every second day until the day of sacrifice. The ABR was used in pups to measure the hearing threshold using a broad range of stimulus intensities and latency at 100 and 80 dB in response to 2, 4, 8, 16, and 32 kHz tone pips at PNd24 and 84. RESULTS AND DISCUSSION: No significant difference between dietary groups was measured in hearing threshold and absolute latencies in pups at PNd24 and PNd84. Although the ID offspring (n = 16) did not differ in brainstem transmission times (BTTs) at 80 dB compare to the IS siblings (n = 25) at PNd24, they showed significant delayed inter-peak latency (IPL) I-IV at 100 dB suggesting a delayed BTT. At PNd84, the latency of all peaks including IPL I-IV at 80 and 100 dB significantly decreased and was also similar in pups from both dietary groups suggesting a better brain maturation. This is the first study investigating the long-term impact of maternal iron deficiency on the auditory functions in the guinea pig offspring during early development to adulthood.

Asunto(s)

Anemia Ferropénica/fisiopatología , Umbral Auditivo , Complicaciones Hematológicas del Embarazo/fisiopatología , Efectos Tardíos de la Exposición Prenatal/fisiopatología , Anemia Ferropénica/complicaciones , Animales , Potenciales Evocados Auditivos del Tronco Encefálico , Femenino , Cobayas , Hierro de la Dieta/administración & dosificación , Masculino , Embarazo

RESUMEN

Iron deficiency (ID) has been reported as a risk factor in the pathology of attention-deficit/hyperactivity disorder, although the mechanisms seem unclear. Previous results from our research group showed that guinea pig offspring born from ID dams were significantly more active in the Open Field Test than the controls. This behavior could potentially be associated to stress. We therefore hypothesized that maternal iron deficiency (MID) elevates the offspring serum cortisol, a biomarker of stress, during childhood and possibly at mature age. Twenty-four female guinea pigs were fed an iron-sufficient (IS) diet (114 mg/kg) or ID diet (11.7 mg/kg) during the gestation and lactation. Pups in both groups were weaned at postnatal day (PNd) 9 and given an IS diet. Hematocrit and serum cortisol levels were measured in dams at every trimester of gestation and in pups at PNd24 and 84. We found no impact of MID on dam's cortisol values. However, our findings indicate that MID increased cortisol secretion in the offspring during childhood, cortisol values being significantly elevated in ID than IS pups at PNd24 (P < .05). During adulthood (PNd84), both groups showed comparable cortisol levels. The elevated cortisol secretion observed in the offspring born from ID mothers during childhood may indicate increased stress reactivity which may have contributed to the higher level of activity when tested in a novel open environment. These findings suggest that MID can potentially act as internal stressor affecting the early development conceivably leading to increased stress levels in the children.

Asunto(s)

Anemia Ferropénica/complicaciones , Hidrocortisona/sangre , Deficiencias de Hierro , Lactancia , Efectos Tardíos de la Exposición Prenatal/sangre , Fenómenos Fisiologicos de la Nutrición Prenatal , Estrés Psicológico/etiología , Fenómenos Fisiológicos Nutricionales de los Animales , Animales , Conducta Animal , Dieta , Femenino , Cobayas , Hierro/administración & dosificación , Masculino , Embarazo , Efectos Tardíos de la Exposición Prenatal/psicología , Estrés Psicológico/sangre , Destete

RESUMEN

OBJECTIVES: We previously demonstrated that a mild pre-natal/early post-natal iron-deficient anaemic (IDA) diet devoid of long-chain polyunsaturated fatty acids (LC-PUFA) affected development, neurophysiology, and cerebral lipid biochemistry of the guinea pigs' progeny. Impacts of dietary LC-PUFA on altered cerebral development resulting from pre-natal IDA are unknown. To address this health issue, impacts of mild gestational IDA in the presence of dietary LC-PUFA on the offsprings' neural maturation were studied in guinea pigs using auditory brainstem responses (ABRs) and assessments of brain fatty acids (FAs). METHODS: Female guinea pigs (n = 10/group) were fed an iron sufficient (IS) or IDA diet (146 and 12.7 mg iron/kg, respectively) with physiological amounts of LC-PUFA, during the gestation and lactation periods. From post-natal day (PNd) 9 onwards, the IS + PUFA diet was given to both groups of weaned offspring. Cerebral tissue and offsprings' ABR were collected on PNd24. RESULTS: There was no difference in peripheral and brainstem transmission times (BTTs) between IS + PUFA and IDA + PUFA siblings (n = 10/group); the neural synchrony was also similar in both groups. Despite the absence of differences in auditory thresholds, IDA + PUFA siblings demonstrated a sensorineural hearing loss in the extreme range of frequencies (32, 4, and 2 kHz), as well as modified brain FA profiles compared to the IS + PUFA siblings. DISCUSSION: The present study reveals that siblings born from dams exposed to a moderate IDA diet including balanced physiological LC-PUFA levels during pregnancy and lactation demonstrate minor impairments of ABR compared to the control siblings, particularly on the auditory acuity, but not on neural synchrony, auditory nerve velocity and BTT.

Asunto(s)

Anemia Ferropénica/fisiopatología , Corteza Auditiva/fisiopatología , Tronco Encefálico/fisiopatología , Ácidos Grasos Esenciales/uso terapéutico , Lactancia , Fenómenos Fisiologicos Nutricionales Maternos , Neurogénesis , Anemia Ferropénica/prevención & control , Animales , Corteza Auditiva/metabolismo , Umbral Auditivo , Tronco Encefálico/metabolismo , Ácidos Grasos Esenciales/metabolismo , Ácidos Grasos Omega-3/metabolismo , Ácidos Grasos Omega-3/uso terapéutico , Ácidos Grasos Omega-6/metabolismo , Ácidos Grasos Omega-6/uso terapéutico , Femenino , Desarrollo Fetal , Cobayas , Pérdida Auditiva Sensorineural/etiología , Pérdida Auditiva Sensorineural/metabolismo , Pérdida Auditiva Sensorineural/fisiopatología , Pérdida Auditiva Sensorineural/prevención & control , Hierro de la Dieta/uso terapéutico , Masculino , Neuronas , Embarazo , Distribución Aleatoria , Transmisión Sináptica , Destete

RESUMEN

The objective of the current study was to determine whether prenatal iron deficiency induced during gestation in guinea pigs affected locomotor activity and learning and memory processes in the progeny. Dams were fed either iron-deficient anemic or iron-sufficient diets throughout gestation and lactation. After weaning, all pups were fed an iron-sufficient diet. On postnatal day 24 and 40, the pups' locomotor activity was observed within an open-field test, and from postnatal day 25 to 40, their learning and memory processes were assessed within a Morris Water Maze. The behavioural and cognitive tests revealed that the iron deficient pup group had increased locomotor activity, but solely on postnatal day 40, and that there were no group differences in the Morris Water Maze. In the general discussion, we propose that prenatal iron deficiency induces an increase in nervousness due to anxiety in the progeny, which, in the current study, resulted in an increase of locomotor activity.

Asunto(s)

Anemia Ferropénica/fisiopatología , Ansiedad/etiología , Aprendizaje por Laberinto , Memoria , Actividad Motora , Fenómenos Fisiologicos de la Nutrición Prenatal , Anemia Ferropénica/complicaciones , Animales , Femenino , Cobayas , Masculino , Embarazo

RESUMEN

OBJECTIVES: It is well known that postnatal/early childhood iron deficiency (ID) anaemia (IDA) adversely affects infants' cognitive development and neurophysiology. However, the effects of IDA during gestation and lactation on the offspring are largely unknown. To address this health issue, the impact of mild IDA during gestation and lactation on the offsprings' neural maturation was studied in the guinea pig, using auditory brainstem responses (ABRs) latencies and amplitudes. METHODS: Female guinea pigs (n = 10/group) were fed an iron sufficient (ISD) or deficient diet (IDD) (144 and 11.7 mg iron/kg) during the gestation and lactation periods. From postnatal day (PNd) 9 onward, the ISD was given to both groups of weaned offspring. The offsprings' ABRs were collected on PNd24 using a broad range of stimulus intensities in response to 2, 4, 8, 16, and 32 kHz tone pips. RESULTS: Although the IDA siblings (n = 8) did not differ in brainstem transmission times (BTTs) compared to the IS siblings (n = 8), they showed significant delayed peak I latency at 100 and 80 dB, respectively. Additionally, significantly higher ABR wave amplitudes were observed in the IDA female offspring between 35 and 50 dB (4 kHz), a phenomenon suggestive of a neural hyperactivity (hyperacusis). DISCUSSION: In support to our previous findings, the present results indicate that a mild IDA during gestation and lactation can have detrimental effects on early development of the offsprings' hearing and nervous systems, particularly on neural synchrony and auditory nerve conduction velocity, but not on BTT.

Asunto(s)

Anemia Ferropénica/fisiopatología , Nervio Coclear/fisiopatología , Potenciales Evocados Auditivos del Tronco Encefálico , Lactancia , Complicaciones Hematológicas del Embarazo , Animales , Tronco Encefálico/fisiopatología , Dieta , Femenino , Cobayas , Hierro de la Dieta/administración & dosificación , Modelos Animales , Embarazo

RESUMEN

PURPOSE: The dietary nutrients iron and long-chain polyunsaturated fatty acids are believed to play an important role in early brain development. We investigated the relationship between pregnant women's iron and docosahexaenoic acid (DHA) status and their infants' cognitive performance at age six months. METHODS: Blood iron and DHA status were analyzed in pregnant women at 28 to 32 weeks of gestation. The women's dietary habits, sociodemographic background, and cognitive performance were assessed using questionnaires. At age six months, infants' blood hemoglobin was analyzed, feeding practices assessed, and weight, length, and head circumference recorded. Each infant's cognitive performance was assessed using the Brunet-Lézine Scale of Psychomotor Development of Early Childhood and the Bayley Scales of Infant Development. Sixty-three mother-infant dyads completed the study. RESULTS: During pregnancy, 9.5% of pregnant women were anemic, 34.9% had low iron stores, and 3.2% suffered from iron deficiency anemia. The DHA represented 4.36% and 2.15% in erythrocyte and plasma total fatty acids, respectively. These levels were considered adequate. No significant relationship was observed between gestational iron or DHA status and infants' cognitive performance. CONCLUSIONS: In this small group of infants born to mothers with relatively good feeding practices and a privileged socioeconomic background, cognitive testing with the instruments above was not associated with maternal iron and DHA levels at age six months.

Asunto(s)

Cognición , Ácidos Docosahexaenoicos/sangre , Hierro/sangre , Fenómenos Fisiologicos Nutricionales Maternos , Estado Nutricional , Adulto , Desarrollo Infantil , Femenino , Desarrollo Fetal , Humanos , Lactante , Masculino , Embarazo , Adulto Joven

RESUMEN

Iron deficiency (ID) anemia (IDA) adversely affects different aspects of the nervous system such as myelinogenesis, neurotransmitters synthesis, brain myelin composition, and brain fatty acid and eicosanoid metabolism. Infant neurophysiological outcome in response to maternal IDA is underexplored, especially mild to moderate maternal IDA. Furthermore, most human research has focused on childhood ID rather than prenatal or neonatal ID. Thus, our study evaluated the consequences of mild maternal IDA during pregnancy and lactation on the offsprings' auditory function using the auditory brainstem response (ABR). This technique provides objective measures of auditory acuity, neural transmission times along the peripheral and brainstem portions of the auditory pathway, and postnatal brain maturation. Female guinea pigs (n = 10/group) were fed an iron sufficient diet (ISD) or an iron deficient diet (IDD) (144 and 11.7 mg iron/kg) during their acclimation, gestation, and lactation periods. From postnatal d (PNd) 9 onward, the ISD was given to all weaned offspring. ABR were collected from the offspring on PNd24 using a broad range of stimulus intensities in response to 2, 4, 8, 16, and 32 kHz tone pips. IDA siblings (n = 4), [corrected] compared with the IS siblings (n = 5), had significantly elevated ABR thresholds (hearing loss) in response to all tone pips. These physiological disturbances were primarily due to a sensorineural hearing loss, as revealed by the ABR's latency-intensity curves. These results indicate that mild maternal IDA during gestation and lactation altered the hearing and nervous system development of the young offspring.

Asunto(s)

Anemia Ferropénica/sangre , Anemia Ferropénica/complicaciones , Potenciales Evocados Auditivos del Tronco Encefálico/fisiología , Lactancia/sangre , Complicaciones Hematológicas del Embarazo/sangre , Efectos Tardíos de la Exposición Prenatal/fisiopatología , Animales , Encéfalo/crecimiento & desarrollo , Modelos Animales de Enfermedad , Femenino , Cobayas , Trastornos de la Audición/etiología , Trastornos de la Audición/fisiopatología , Humanos , Masculino , Embarazo

RESUMEN

Iron deficiency (ID) is the most prevalent worldwide nutritional deficiency. Groups at risk of developing ID anemia are infants and pregnant women, even in industrialized countries. Our goal in this study was to evaluate the long-term consequences of maternal ID on the offspring's fatty acid and eicosanoid metabolism, behavior, and spatial memory. Female guinea pigs consumed iron-sufficient (IS) and -deficient (ID) diets for 14 d before mating and throughout pregnancy and lactation. Dietary iron restriction resulted in ID in pregnant females. On postnatal d 9, all offspring (ID and IS) were weaned to the IS diet and at 42 d, all offspring were iron replete. Locomotion was tested in pups on postnatal d 24 and 40 and spatial memory from d 25 to 40. Pups from the ID group were significantly more active in the open field at both times of testing, whereas spatial memory, tested in a Morris water maze, was comparable in both groups. On postnatal d 42, liver, RBC, and brain fatty acid composition were measured. Dihomogammalinolenic [20:3(n-6)], docosapentaenoic [22:5(n-3)], and docosahexaenoic [22:6(n-3)] acid contents were significantly higher in brain phospholipids of offspring born to ID dams. Prostaglandin E(2) and F(2alpha) concentrations were also significantly higher in brains of offspring born to ID dams. This demonstrates that moderate ID during gestation and lactation results in alterations of brain fatty acid and eicosanoid metabolism and perturbation in behavior in adult offspring.

Asunto(s)

Anemia Ferropénica/metabolismo , Encéfalo/metabolismo , Ácidos Grasos/metabolismo , Deficiencias de Hierro , Hierro de la Dieta/metabolismo , Locomoción/fisiología , Efectos Tardíos de la Exposición Prenatal/metabolismo , Animales , Conducta Animal , Dieta , Eritrocitos/metabolismo , Ácidos Grasos Omega-3/metabolismo , Femenino , Cobayas , Hierro/metabolismo , Hígado/metabolismo , Masculino , Aprendizaje por Laberinto , Memoria , Fosfolípidos/metabolismo , Embarazo , Prostaglandinas/metabolismo

RESUMEN

PURPOSE: To evaluate initiation and duration of breastfeeding of infants born to mothers who participated in the Early Childhood Initiative (ECI) program. Factors affecting the initiation and the early cessation of breastfeeding were also explored. METHODS: Twenty-five pregnant women participating in the ECI program completed this prospective study. At 36 weeks' gestation, a questionnaire was administered to assess socioeconomic status, intention to breastfeed and breastfeeding experience. When the infants were three and six months of age, feeding practices were assessed with a questionnaire. RESULTS: The breastfeeding initiation rate was 62.5%. At one and three months postpartum, exclusive breastfeeding rates were 39% and 4%, respectively. At six months, none of the women was exclusively breastfeeding. Primiparity, prenatal classes, having been breastfed and intention to breastfeed at 36 weeks' gestation were positively associated with breastfeeding initiation. Father's education, intention to breastfeed at 36 weeks' gestation, no water or formula given to the infant during hospitalization and higher maternal hemoglobin level at 36 weeks' gestation were positively associated with the duration of breastfeeding. CONCLUSIONS: The rate of initiation and duration of breastfeeding for ECI participants were low. To achieve successful interventions, it is important to target modifiable factors known to influence the initiation and duration of breastfeeding within this population.

Asunto(s)

Lactancia Materna/epidemiología , Ciencias de la Nutrición del Niño/educación , Fenómenos Fisiológicos Nutricionales del Lactante/fisiología , Intención , Atención Prenatal , Adolescente , Adulto , Lactancia Materna/psicología , Lactancia Materna/estadística & datos numéricos , Escolaridad , Femenino , Promoción de la Salud , Humanos , Lactante , Recién Nacido , Masculino , Conducta Materna , Embarazo , Tercer Trimestre del Embarazo , Estudios Prospectivos , Factores Socioeconómicos , Encuestas y Cuestionarios , Factores de Tiempo

RESUMEN

PURPOSE: Iron deficiency anemia (IDA) during pregnancy and infancy is still common in developed countries, especially in low-income groups. We examined the prevalence of anemia and IDA in healthy low-income pregnant women participating in the Early Childhood Initiatives (ECI) program, and in their infants when they reached six months of age. METHODS: Pregnant women were recruited by nutritionists. In mothers, hemoglobin (Hb), mean corpuscular volume, and serum ferritin (SF) were measured at 36 +/- 2 weeks of gestation. In infants, Hb, mean corpuscular volume, SF, serum iron, total iron binding capacity (TIBC), and transferrin saturation (TS) were measured at six months of age. Thirty-one mother-infant pairs participated. RESULTS: Among the 31 pregnant women participating in the ECI program, six (19.4%) were anemic (Hb <110 g/L) and five (16.1%) suffered from IDA (Hb <110 g/L and SF <10 microg/L). Among infants, seven of 23 (30.4%) were anemic (Hb <110 g/L) and five of 23 (21.7%) suffered from IDA (Hb <110 g/L plus two of the following: TIBC >60 micromol/L, SF <10 microg/L, serum iron <5.3 micromol/L, TS < or = 15%). CONCLUSIONS: The prevalence of anemia in this group of low-income pregnant women is comparable to that in privileged women. The prevalence of IDA in infants is comparable to that observed in other high-risk groups. Effective strategies are needed to prevent IDA in vulnerable groups.

Asunto(s)

Anemia Ferropénica/epidemiología , Trastornos de la Nutrición del Lactante/sangre , Hierro/sangre , Complicaciones del Embarazo/sangre , Fenómenos Fisiologicos de la Nutrición Prenatal/fisiología , Adulto , Anemia Ferropénica/prevención & control , Femenino , Ferritinas/análisis , Hemoglobinas/análisis , Humanos , Lactante , Trastornos de la Nutrición del Lactante/epidemiología , Trastornos de la Nutrición del Lactante/prevención & control , Recién Nacido , Masculino , Nueva Caledonia/epidemiología , Paridad , Pobreza , Embarazo , Complicaciones del Embarazo/epidemiología , Complicaciones del Embarazo/prevención & control , Prevalencia , Factores de Riesgo , Transferrina/análisis

RESUMEN

Iron-deficiency anemia is still prevalent among pregnant women living in industrialized countries such as Canada. To prevent this deficiency, iron supplements (30 mg/d) are routinely prescribed to Canadian pregnant women. Recently, dietary reference intakes for iron have increased from 18 and 23 mg/d during the second and third trimesters, respectively, to 27 mg/d throughout the pregnancy for all age groups. Whether this new recommendation implies an increase of iron dosage in supplements has not been answered. Are there any benefits or risks for the mother and her infant associated with iron supplementation during pregnancy? If iron supplementation is recommended, what should be the ideal dosage? This article reviews current knowledge on the potential negative or positive impact of iron supplementation during pregnancy on the outcomes of both infants and mothers. Based on the literature reviewed, a low daily dose of iron (30 mg elemental iron) during pregnancy improves women's iron status and seems to protect their infants from iron-deficiency anemia. Several studies have also shown that a low daily dose of iron may improve birth weight even in non-anemic pregnant women. However, higher dosages are not recommended because of the potential negative effects on mineral absorption, oxidative pathways, and adverse gastrointestinal symptoms. To date, it is still not clear if health professionals should recommend routine or selective supplementation. However, neither routine nor selective iron supplementation during pregnancy is able to eliminate iron-deficiency anemia. Even though the dietary reference intake for iron during pregnancy has been recently increased, we do not recommend higher doses of iron in supplements designed for pregnant women.

Asunto(s)

Anemia Ferropénica/prevención & control , Suplementos Dietéticos , Hierro/uso terapéutico , Canadá , Femenino , Gastritis/inducido químicamente , Humanos , Recién Nacido , Hierro/efectos adversos , Embarazo , Resultado del Embarazo , Medición de Riesgo

RESUMEN

PURPOSE: Factors associated with early cessation of breastfeeding were identified and patterns of infant feeding were examined. Feeding practices were compared with the 1998 guidelines in Nutrition for Healthy Term Infants and with recent Health Canada recommendations. METHODS: To recruit participants, a letter was sent to every mother (n=424) who gave birth at Dr. Georges-L. Dumont Regional Hospital in Moncton from April 1998 to February 1999. Eighty-five mothers agreed to participate with their infants. Information on infant feeding patterns and socioeconomic background was gathered with semi-structured questionnaires. Only healthy infants from singleton pregnancies were included in this study. RESULTS: At birth, almost 83% of infants were breastfed. The proportions of infants breastfed for at least four, six, and nine months were 43%, 22%, and 9%, respectively. As many as 34% of infants were introduced to baby cereals before age four months, and 21% were introduced to cow's milk before age nine months. Lower family income, lower level of parental education, and reduced postpartum hemoglobin level (below 95 g/L) were associated with discontinuation of breastfeeding before infants were four months old. CONCLUSIONS: Early postpartum nutrition interventions may be effective in ensuring follow-up care for mothers with compromised iron status, in supporting breastfeeding for at least six months, and in promoting better infant feeding practices.

Asunto(s)

Anemia/complicaciones , Anemia/epidemiología , Lactancia Materna , Destete , Adulto , Lactancia Materna/estadística & datos numéricos , Escolaridad , Femenino , Humanos , Lactante , Alimentos Infantiles , Recién Nacido , Masculino , Proyectos Piloto , Periodo Posparto , Factores Socioeconómicos , Encuestas y Cuestionarios , Factores de Tiempo

RESUMEN

UNLABELLED: Marginal intake of iron and omega-3 long-chain fatty acids (DHA) is prevalent among pregnant women. It is not clear to what extent poor iron or DHA status during pregnancy impacts on an infant's functional outcomes. A few studies suggest that inadequate maternal iron or DHA status may be associated with suboptimal functional outcomes in infants. In addition, there is a lack of prospective studies using randomized, double-blind design or experimental studies with appropriate animal models. Although both nutrients are involved in early brain development and their metabolism is interrelated, no study has examined the interaction between iron and omega-3 fatty acids during pregnancy. CONCLUSION: Long-term studies on large cohorts of pregnant women and their infants are needed to determine whether inadequate iron or DHA status during pregnancy is detrimental to infant neurodevelopment.

Asunto(s)

Encéfalo/metabolismo , Desarrollo Infantil/fisiología , Discapacidades del Desarrollo/etiología , Ácidos Grasos Omega-3/uso terapéutico , Deficiencias de Hierro , Hierro/metabolismo , Femenino , Humanos , Lactante , Recién Nacido , Recien Nacido Prematuro , Madres , Embarazo

RESUMEN

BACKGROUND: Iron-deficiency anemia during pregnancy is still common in developed countries. The aim of this study was to evaluate the influence of maternal anemia on the infant's iron status at 9 months of age in Moncton, NB. METHODS: Mothers giving birth between April 1998 and February 1999 were selected from medical records. A letter was sent to invite them to participate. In total, 75 mothers with their infants were examined. RESULTS: The proportion of iron-deficiency anemia was higher (p = 0.055) in the group born to anemic compared to non-anemic mothers. A positive association between the mother's haemoglobin and haematocrit during her 3rd trimester and her infant's haemoglobin and haematocrit was found at 9 months of age. These results are not explained by differences in feeding practices and socio-economic status between groups. INTERPRETATION: Infants born to mildly anemic mothers may be at risk of developing anemia.

Asunto(s)

Anemia Ferropénica/sangre , Anemia Ferropénica/epidemiología , Bienestar del Lactante/estadística & datos numéricos , Complicaciones del Embarazo/sangre , Adulto , Anemia Ferropénica/complicaciones , Estudios de Casos y Controles , Femenino , Humanos , Lactante , Intercambio Materno-Fetal , Nuevo Brunswick , Embarazo , Tercer Trimestre del Embarazo , Factores de Riesgo , Clase Social , Encuestas y Cuestionarios