RESUMEN

This report describes a new method, the splay angle measures, to determine neuromuscular dysfunction. Splay angles are measured from a standard splay test and define hind limb orientation quantified, in degrees, by the paw strike of the hind limbs. We used mutant rats, presenting with a chronic central nervous system demyelinating disease, characterized by tremor, ataxia, immobility, epilepsy, and paralysis (taiep). Significant differences between taiep (n = 12) and normal control rats (n = 10) were found for Linear Splay, AngleLeft, AngleRight, and AngleBoth. These results suggest that the splay angles are a sensitive measure of hind limb orientation and may reflect an underlying pathology.

Asunto(s)

Miembro Posterior/fisiología , Enfermedades Neuromusculares/diagnóstico , Animales , Femenino , Masculino , Mutación/fisiología , Enfermedades Neuromusculares/genética , Enfermedades Neuromusculares/fisiopatología , Ratas , Ratas Sprague-Dawley , Reproducibilidad de los Resultados , Caracteres Sexuales