RESUMEN
PURPOSE: Animal bites to the external genitalia are rare. We retrospectively evaluated our experience with treating genital trauma caused by animal attacks. MATERIALS AND METHODS: We studied the medical records of 10 patients treated in the surgical emergency department at our hospital who presented with genital injury caused by an animal bite from 1983 to 1999. Special attention was given to the severity of injury, surgical treatment, antibiotic prophylaxis and outcome. RESULTS: Of the 2 men and 8 boys 8 were attacked by dogs, 1 by a horse and 1 by a donkey, respectively. In all cases initial local treatment involved débridement and copious wound irrigation with saline and povidone-iodine solution. Five patients who presented with minimal or no skin loss underwent primary skin closure, including 2 in whom urethral lacerations were surgically repaired. There was moderate to extensive tissue loss in 5 patients, including degloving penile injury in 2, traumatic spermatic cord amputation in 1, complete penile and scrotal avulsion in a 5-month-old infant, and partial penectomy in 1. Reconstructive procedures provided satisfactory cosmetic and functional results in 8 cases. Antibiotic prophylaxis was administered in all patients and no infectious complications developed. CONCLUSIONS: Animal bite is a rare but potentially severe cause of genital trauma and children are the most common victims. Morbidity is directly associated with the severity of the initial wound. Because patients tend to seek medical care promptly, infectious complications are unusual. Management involves irrigation, débridement, antibiotic prophylaxis, and tetanus and rabies immunization as appropriate as well as primary wound closure or surgical reconstruction. Good functional and cosmetic results are possible in the majority of cases.
Asunto(s)
Mordeduras y Picaduras/complicaciones , Genitales Masculinos/lesiones , Adulto , Amputación Traumática/etiología , Amputación Traumática/cirugía , Animales , Profilaxis Antibiótica , Niño , Desbridamiento , Perros , Equidae , Caballos , Humanos , Masculino , Pene/lesiones , Procedimientos de Cirugía Plástica , Estudios Retrospectivos , Irrigación TerapéuticaRESUMEN
We observed that the purified venom of the Tityus serrulatus scorpion (T1 fraction), injected i.v. in rats, in a single dose of 0.5 mg/kg, produces: acute pancreatitis, characterized by degranulation and acinar cell vacuolization, necrosis and an inflammatory reaction, 24, 48 and 96 hours after the injection; chronic pancreatitis, characterized by interstitial fibrosis, lymphocyte infiltration, ductal and ductular dilation, acinar cell atrophy, periductal ductular hyperplasia, 20 days after injection: hyperplasia of Langerhans' islets and nesidioblastosis, associated to chronic pancreatitis. The absence of deaths in the experimental group is an interesting finding: the dose used preserved the animals from death and allowed the safe follow-up of the progression of the provoked pancreatitis. The results led us to conclude that the toxin of Tityus serrulatus scorpion is an agent of considerable efficacy in the induction of pancreatitis in rats providing an experimental model of acute and chronic form of this disease.
Asunto(s)
Pancreatitis/inducido químicamente , Venenos de Escorpión/administración & dosificación , Toxinas Biológicas/administración & dosificación , Enfermedad Aguda , Animales , Enfermedad Crónica , Modelos Animales de Enfermedad , Masculino , Pancreatitis/patología , Ratas , Ratas Wistar , Factores de TiempoRESUMEN
Tityustoxin (TsTx), the purified venom of the Brazilian scorpion Tityus serrulatus, was injected intravenously (50 micrograms/kg) into rats, producing a typical picture of chronic pancreatitis after 20 days. Nesidioblastosis, a lesion characterized by hyperplasia of the islets of Langerhans, was also detected in a high percentage (40%) of animals. TsTx-induced pancreatitis may be a useful model for the study of nesidioblastosis in laboratory animals.
Asunto(s)
Enfermedades Pancreáticas/patología , Pancreatitis/inducido químicamente , Venenos de Escorpión/toxicidad , Animales , Enfermedad Crónica , Inyecciones Intravenosas , Masculino , Pancreatitis/patología , RatasRESUMEN
Tityustoxin (TsTx), the purified venom of the Brazilian scorpion Tityus serrulatus, was inected intravenously (50 microng/Kg) into rats, producing a typical picture of chronic pancreatitis after 20 days. Nesidioblastosis, a lesions characterized by hyperplasia of the islets of Langerhans, was also detected in a high percentage (40%) of animals. TsTx-induced pancreatitis may be a useful model for the study of nesidioblastosis in laboratory animals