RESUMEN
The authors studied functional characteristics of mononuclear leucocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. The study found decrease of the number of C3b- and Fcchi-receptorpositive monocytes and increase of their saturation activity in both categories of pulmonary tuberculosis before and after antituberculous therapy. The study revealed increase of interferons alpha and chi production and, at the same time, decrease of tumor necrosis factor alpha, which was more prominent in cases of drug-sensitive tuberculosis, and depression of interleukin 2 secretion, more prominent during chemotherapy in cases of drug-resistant tuberculosis.
Asunto(s)
Leucocitos Mononucleares/metabolismo , Tuberculosis Resistente a Múltiples Medicamentos/sangre , Tuberculosis Pulmonar/sangre , Adulto , Antituberculosos/uso terapéutico , Biomarcadores/sangre , Femenino , Humanos , Interferón-alfa/metabolismo , Interleucina-2/metabolismo , Masculino , Persona de Mediana Edad , Receptores de Complemento 3b/metabolismo , Receptores Fc/metabolismo , Tuberculosis Pulmonar/tratamiento farmacológicoRESUMEN
The cytogenic status of peripheral lymphocytes was studied in 67 patients with drug-sensitive pulmonary tuberculosis. The latter was found to be attended by cytogenetic disorganization whose signs were present before and 2 months of intensive chemotherapy. In pulmonary tuberculosis, structural disorganization in the lymphocytic chromosomal apparatus was characterized by the elevated levels of cells and with changes in the structure and number of chromosomes. They are most pronounced in infiltrative and disseminated tuberculosis than in caseous pneumonia, as well as 2 months after rather than before chemotherapy. Patients with infiltrative pulmonary tuberculosis had also decreased lymphocytic activity of DNA reparation, followed by its normalization after a course of chemotherapy.