RESUMEN
Las nefritis intersticiales granulomatosas son entidades con escasa incidencia en la clínica habitual; suelen asociarse con cuadros infecciosos, como la tuberculosis, trastornos inmunológicos, como la sarcoidosis, el lupus eritematoso sistémico o la crioglobulinemia y, más frecuentemente, con el uso de fármacos, sobre todo los antibióticos, los inhibidores de la bomba de protones o los antiinflamatorios no esteroideos; no se ha descrito su asociación con el uso de agentes procinéticos. Presentamos el caso de una paciente de 64 años de edad que desarrolla este cuadro tras la toma de cinitaprida, un estimulador de la motilidad intestinal que ingería sin conocimiento de su médico
Granulomatous interstitial nephritides are uncommon entities in routine clinical practice. These entities are usually associated with infectious diseases such as tuberculosis, or immune diseases, such as sarcoidosis, systemic lupus erythematosus or cryoglobulinemia. However, these diseases are most frequently associated with drug intake, especially antibiotics, proton pump inhibitors and nonsteroidal anti inflammatory drugs. An association with prokinetic agents has not previously been reported. We report the case of a 64-year-old woman who developed acute renal failure with this histological pattern after taking the motility promoter cinitapride without her physician's knowledge
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Nefritis Intersticial/inducido químicamente , Fármacos Gastrointestinales/efectos adversos , Cirrosis Hepática/complicaciones , Cirrosis Hepática/tratamiento farmacológico , Corticoesteroides/uso terapéutico , Diagnóstico DiferencialRESUMEN
Granulomatous interstitial nephritides are uncommon entities in routine clinical practice. These entities are usually associated with infectious diseases such as tuberculosis, or immune diseases, such as sarcoidosis, systemic lupus erythematosus or cryoglobulinemia. However, these diseases are most frequently associated with drug intake, especially antibiotics, proton pump inhibitors and nonsteroidal anti inflammatory drugs. An association with prokinetic agents has not previously been reported. We report the case of a 64-year-old woman who developed acute renal failure with this histological pattern after taking the motility promoter cinitapride without her physician's knowledge.