RESUMEN
The internalizing construct captures shared variance underlying risk for mood and anxiety disorders. Internalizing factors based on diagnoses (or symptoms) of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are well established. Studies have also integrated self-reported measures of associated traits (e.g., questionnaires assessing neuroticism, worry, and rumination) onto these factors, despite having not tested the assumption that these measures truly capture the same sets of risk factors. This study examined the overlap among both sets of measures using converging approaches. First, using genomic structural equation modeling, we constructed internalizing factors based on genome-wide association studies (GWASs) of internalizing diagnoses (e.g., MDD) and traits associated with internalizing (neuroticism, loneliness, and reverse-scored subjective well-being). Results indicated the two factors were highly (rg = .79) but not perfectly genetically correlated (rg < 1.0, p < .001). Second, we constructed similar latent factors in a combined twin/adoption sample of adults from the Colorado Adoption/Twin Study of Lifespan Behavioral Development and Cognitive Aging. Again, both factors demonstrated strong overlap at the level of genetic (rg = .76, 95% confidence interval [CI] [0.40, 0.97]) and nonshared environmental influences (re = .80, 95% CI [0.53, 1.0]). Shared environmental influences were estimated near zero for both factors. Our findings are consistent with current frameworks of psychopathology, though they suggest there are some unique genetic influences captured by internalizing diagnosis compared to trait measures, with potentially more nonadditive genetic influences on trait measures. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Asunto(s)
Trastornos de Ansiedad , Trastorno Depresivo Mayor , Estudio de Asociación del Genoma Completo , Autoinforme , Humanos , Masculino , Adulto , Femenino , Trastornos de Ansiedad/genética , Trastornos de Ansiedad/psicología , Trastornos de Ansiedad/epidemiología , Trastornos de Ansiedad/diagnóstico , Trastorno Depresivo Mayor/genética , Trastorno Depresivo Mayor/psicología , Trastorno Depresivo Mayor/diagnóstico , Trastorno Depresivo Mayor/epidemiología , Persona de Mediana Edad , Neuroticismo , Gemelos/genética , Gemelos/psicología , AncianoRESUMEN
Developing self-restraint, or the inhibition of behavior in response to a prohibition, is an important process during toddlerhood. The objective of this study was to gain a better understanding of individual differences in the development of self-restraint during toddlerhood by examining stable elements and growth of temperament (i.e., attentional control, behavioral inhibition, negative emotionality), general intelligence, and self-restraint. Participants were 412 same-sex twin pairs (approximately 90% European American) from predominately middle-class households in Colorado. Data were collected at 14, 20, 24, and 36 months. Results indicated that higher behavioral inhibition, attentional control, and intelligence were independently associated with better self-restraint, whereas higher negative emotionality was an independent predictor of lower self-restraint. The associations between temperament and self-restraint generally appeared to be stable from 14 to 36 months.
Asunto(s)
Atención/fisiología , Conducta Infantil/fisiología , Inhibición Psicológica , Inteligencia/fisiología , Autocontrol , Temperamento/fisiología , Preescolar , Femenino , Humanos , Lactante , Estudios Longitudinales , MasculinoRESUMEN
Studies have reported an inverse association between language development and behavioral inhibition or shyness across childhood, but the direction of this association remains unclear. This study tested alternative hypotheses regarding this association in a large sample of toddlers. Data on behavioral inhibition and expressive and receptive language abilities were collected from 816 twins at ages 14, 20, and 24 months. Growth and regression models were fit to the data to assess the longitudinal associations between behavioral inhibition and language development from 14 to 24 months. Overall, there were significant associations between behavioral inhibition and expressive language, and minimal associations with receptive language, indicating that the association is better explained by reticence to respond rather than deficient language development.
Asunto(s)
Conducta Infantil/fisiología , Inhibición Psicológica , Desarrollo del Lenguaje , Preescolar , Femenino , Humanos , Lactante , Masculino , Modelos PsicológicosRESUMEN
Several researchers have suggested that the nature of the covariation between internalizing and externalizing disorders may be understood better by examining the associations between temperament or personality and these disorders. The present study examined neuroticism as a potential common feature underlying both internalizing and externalizing disorders and novelty seeking as a potential broad-band specific feature influencing externalizing disorders alone. Participants were 12- to 18-year-old twin pairs (635 monozygotic twin pairs and 691 dizygotic twin pairs; 48 % male and 52 % female) recruited from the Colorado Center for Antisocial Drug Dependence. Genetic and nonshared environmental influences shared in common with neuroticism influenced the covariation among distinct internalizing disorders, the covariation among distinct externalizing disorders, and the covariation between internalizing and externalizing disorders. Genetic influences shared in common with novelty seeking influenced the covariation among externalizing disorders and the covariation between major depressive disorder and externalizing disorders, but not the covariation among internalizing disorders or between anxiety disorders and externalizing disorders. Also, after accounting for genetic and environmental influences shared in common with neuroticism and novelty seeking, there were no significant common genetic or environmental influences among the disorders examined, suggesting that the covariance among the disorders is sufficiently explained by neuroticism and novelty seeking. We conclude that neuroticism is a heritable common feature of both internalizing disorders and externalizing disorders, and that novelty seeking is a heritable broad-band specific factor that distinguishes anxiety disorders from externalizing disorders.
Asunto(s)
Trastornos de Ansiedad/epidemiología , Trastornos de Ansiedad/genética , Enfermedades en Gemelos/epidemiología , Enfermedades en Gemelos/genética , Conducta Exploratoria , Trastornos Mentales/epidemiología , Trastornos Mentales/genética , Adolescente , Trastornos de Ansiedad/psicología , Ansiedad de Separación/epidemiología , Ansiedad de Separación/genética , Ansiedad de Separación/psicología , Déficit de la Atención y Trastornos de Conducta Disruptiva/epidemiología , Déficit de la Atención y Trastornos de Conducta Disruptiva/genética , Déficit de la Atención y Trastornos de Conducta Disruptiva/psicología , Niño , Colorado/epidemiología , Trastorno Depresivo Mayor/epidemiología , Trastorno Depresivo Mayor/genética , Trastorno Depresivo Mayor/psicología , Enfermedades en Gemelos/psicología , Ambiente , Femenino , Predisposición Genética a la Enfermedad , Humanos , Masculino , Trastornos Mentales/psicología , Análisis Multivariante , Neuroticismo , Personalidad , Factores de Riesgo , TemperamentoRESUMEN
Behavioral inhibition is a temperamental trait that refers to slow approach to novel items, shyness towards new people, and fearfulness in new situations, and individuals may develop inhibited response styles by as early as 2 years of age. There are important methodological considerations in the assessment of early temperament, with parental report and observational measures providing both corroborative and unique data. The present study examined behavioral inhibition measured by parental report and observational measures in a genetically informative sample to delineate the agreement between the methods and the uniqueness of each method, and to estimate the magnitude of genetic and environmental influences on the common and unique variance. The biometric, psychometric, and rater bias models were conducted to study the covariance between measurement modalities. Overall, the results suggested a common phenotype was assessed by both parents and observers. The latent phenotype underlying parental and observational measures of behavioral inhibition was moderately to substantially heritable.
Asunto(s)
Conducta/fisiología , Interacción Gen-Ambiente , Inhibición Psicológica , Padres/psicología , Timidez , Preescolar , Análisis Factorial , Femenino , Humanos , Estudios Longitudinales , Masculino , Modelos Psicológicos , Pruebas Neuropsicológicas , Variaciones Dependientes del Observador , Psicometría , Tamaño de la Muestra , Caracteres Sexuales , Encuestas y Cuestionarios , TemperamentoRESUMEN
BACKGROUND: We investigated the etiological nature of comorbid alcohol, tobacco, and cannabis DSM-IV dependence symptoms in late adolescence and young adulthood while accounting for gender differences in the magnitude of genetic and environmental influences. METHODS: Univariate and multivariate twin modeling was used to determine the heritability of each substance and the etiology of multiple drug problems in a sample of 2484 registrants of the Center for Antisocial Drug Dependence who provided data at the second wave of an ongoing longitudinal study. We report on mean and prevalence levels of whole-life DSM-IV dependence symptoms that were assessed with the Composite International Diagnostic Interview-Substance Abuse Module. Biometrical analyses were limited to age-adjusted DSM-IV dependence symptom counts from a subset of twins that reported using alcohol, tobacco, or cannabis in their lifetime. RESULTS: Male and female alcohol, tobacco, and cannabis DSM-IV symptoms are indicators of a heritable unidimensional latent continuous trait. Additive genetic factors explain more than 60% of the common liability to drug dependence. A larger proportion of the variation in each substance is attributable to substance-specific genetic and environmental factors. CONCLUSIONS: These data suggest that both common and substance-specific genetic and environmental factors contribute to individual differences in the levels of DSM-IV alcohol, tobacco, and cannabis dependence symptoms.
Asunto(s)
Alcoholismo/genética , Predisposición Genética a la Enfermedad , Abuso de Marihuana/genética , Tabaquismo/genética , Adolescente , Adulto , Comorbilidad , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Ambiente , Femenino , Humanos , Estudios Longitudinales , Masculino , Análisis Multivariante , Prevalencia , Factores Sexuales , Gemelos , Adulto JovenRESUMEN
Several studies suggest that a two-factor model positing internalizing and externalizing factors explains the interrelationships among psychiatric disorders. However, it is unclear whether the covariation between internalizing and externalizing disorders is due to common genetic or environmental influences. We examined whether a model positing two latent factors, internalizing and externalizing, explained the interrelationships among six psychiatric disorders (major depressive disorder, generalized anxiety disorder, separation anxiety disorder, attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder) in adolescents, and whether there are common genetic and environmental influences on internalizing and externalizing latent factors. Multivariate behavior genetic analyses of data from 1162 twin pairs and 426 siblings ascertained from the general population via the Colorado Center for Antisocial Drug Dependence (CADD) were conducted. We found support for a model positing two latent factors (internalizing and externalizing). These factors were moderately heritable and influenced by significant common genetic and nonshared environmental influences. These findings suggest that co-occurrence of internalizing and externalizing psychopathology in adolescents results from both genetic and environmental influences.
Asunto(s)
Trastornos Mentales/psicología , Adolescente , Factores de Edad , Trastornos de Ansiedad/etiología , Trastornos de Ansiedad/genética , Trastornos de Ansiedad/psicología , Ansiedad de Separación/etiología , Ansiedad de Separación/genética , Ansiedad de Separación/psicología , Trastorno por Déficit de Atención con Hiperactividad/etiología , Trastorno por Déficit de Atención con Hiperactividad/genética , Trastorno por Déficit de Atención con Hiperactividad/psicología , Déficit de la Atención y Trastornos de Conducta Disruptiva/etiología , Déficit de la Atención y Trastornos de Conducta Disruptiva/genética , Déficit de la Atención y Trastornos de Conducta Disruptiva/psicología , Comorbilidad , Trastorno de la Conducta/etiología , Trastorno de la Conducta/genética , Trastorno de la Conducta/psicología , Trastorno Depresivo Mayor/etiología , Trastorno Depresivo Mayor/genética , Trastorno Depresivo Mayor/psicología , Femenino , Humanos , Masculino , Trastornos Mentales/etiología , Trastornos Mentales/genética , Modelos Psicológicos , Factores Sexuales , Hermanos/psicología , Gemelos Dicigóticos/psicología , Gemelos Monocigóticos/psicologíaRESUMEN
BACKGROUND: Previous studies have demonstrated that the heritability of alcohol-related phenotypes depends upon the social background in which it is measured (e.g., urbanicity, marital status, and religiosity). The aim of the current study was to identify whether religiosity moderated the genetic variance of problem alcohol use in men and women at two time points: adolescence and early adulthood. METHOD: Participants were 312 male MZ pairs, 379 female MZ pairs, 231 male DZ pairs, 235 female DZ pairs, and 275 opposite sex DZ pairs participating in the University of Colorado Center on Antisocial Drug Dependence. Religiosity was measured using the Value on Religion Scale (Jessor and Jessor, 1977), and problem alcohol use was measured using the Composite International Diagnostic Interview-Substance Abuse Module (Cottler et al., 1989). Data were analyzed using a model-fitting approach to the twin data. RESULTS: In adolescence, genetic variance of problem alcohol use decreased significantly with increasing levels of religiosity in both men and women, whereas in early adulthood, religiosity did not moderate the genetic variance of problem alcohol use in either men or women. CONCLUSION: Religiosity appears to moderate the genetic effects on problem alcohol use during adolescence, but not during early adulthood. The reduced genetic variance for problem alcohol use in adolescence may be the consequence of greater social control in adolescence than in young adulthood.
Asunto(s)
Alcoholismo/prevención & control , Enfermedades en Gemelos/psicología , Variación Genética , Religión , Adolescente , Conducta del Adolescente , Adulto , Factores de Edad , Alcoholismo/genética , Niño , Enfermedades en Gemelos/genética , Femenino , Humanos , Masculino , Modelos Genéticos , Caracteres Sexuales , Gemelos Dicigóticos/psicología , Gemelos Monocigóticos/psicologíaRESUMEN
The present study is the first to utilize twin modeling to examine whether parent-teacher disagreement for ADHD ratings is due to parent or teacher bias, or due to raters observing different but valid ADHD behaviors. A joint analysis was conducted with 106 twin pairs, including twins selected for ADHD and control twin pairs. Total ADHD scores were analyzed using multiple rater models that estimate genetic and environmental contributions common to both raters and unique to each rater. Results suggest that 1) disagreement in ADHD ratings is strongly due to parents and teachers observing different ADHD behaviors, some of which is valid and some of which is due to bias, and 2) parents may be more biased than teachers in their ADHD ratings.