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The article presents modern data on the causes of platypnea, methods of its diagnosis and treatment. The data on the development of platypnea syndrome are given not only in cardiac pathology, but also in severe liver diseases with the development of hepatopulmonary syndrome and chronic obstructive pulmonary disease of a severe course.

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Contemporary approach to antianginal therapy in patients with stable are reviewed. Benefits and limitations of "standard" antiischemic therapy and evidence-based data about alternative therapy with nicorandil are discussed in details.

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The article deals with violations of general resistance of the organism of military men, who get extramural pneumonia during the battle action. The author analyzed the data of immune status in three groups of soldiers. Statistical analysis of materials led to the conclusion that violations of immunity in the main group depend on the circumstances and nature of military service. This fact indicates that the significant clinical and pathogenetic differences in the development, course and outcome of an extramural pneumonia against the background of chronic adaptation syndrome. Pathogenic peculiarities of patients with pneumonia against the background of the impact of extreme factors of the military conflicts are presented in a prolonged dysfunction of all parts of the immune system.

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Violation of qualitative and quantitative composition of the microflora of the intestinal tract has a negative effect on the body and conduces to formation of pathosis. As a result of our study we have the date which confirmed the relevance between the functional status of hepatobiliary system, status of lipid exchange and violations of the microflora of the large intestine. Therefore, apparently, that the preservation and sustentation of normal microflora of the intestinal tract are the most important components determining the health status of the person and microecological approaches to the understanding of the development of the pathosis can be the starting point of the creation of new methods of treatment.

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The aim of work was examination of peculiarities of outhospital pneumonia (OHP) among military servicemen, participants of local armed conflicts in areas of Prodnestrovie, Tadjikistan, North Ossetia, Abkhazia. There were retrospectively analyzed 139 archive patient histories of military servicemen, got pneumonia during 1990-1993. In structure of OHP of military servicemen predominating was pneumonia with not hard course of disease. Was educes a clear season dependence of appearance of pneumonia in described conditions with it's peculiarities. Each fifth patient form call-up contingent had deficit of weight. It influenced on course of disease. In 40% of cases of OHP there were coexistent diseases. Peculiarities in clinical forms of disease were not found. Using of antibacterial measures in treatment of OHP was empirical, during therapy of acute pneumonia were used 3 antibiotics simultaneously. For a more long-term of treatment had a need soldiers, participants of combat actions on the Northern Caucasus.

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Myocardial infarction and coronary spasm are the main causes of sudden cardiac death among contract servicemen. However, 23% of such cases exhibit no organic pathology. Multifunctional analysis revealed a number of anamnestic, laboratory, and instrumental parameters correlating with sudden death. It is concluded that stratification of risks of sudden cardiac death requires taking into account not only biological and social factors but also some specific ones inherent in military service, such as performing general and command duties, combat missions, military education, night duties, etc.

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Sudden death (SD) rate acquires threatening dimensions in industrialized countries. Upon the average SD rate is about 1 case of 1000 citizens. According to the SD patients autopsy results 85% had coronary heart disease, 10% had other cardiac pathology and 5% did not have any organic heart pathology. One of the SD causes in patients without organic cardiac pathology can be "channelpathy" - clinico-electrocardiographic syndromes, caused by disturbances of ion channel functions.

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Sudden cardiac death (SCD) is a combined conception integrating various nosological forms of cardiac pathology. 80% of SCD cause is coronary heart disease, 20% are various cardiomyopathies, myocarditis, cardiovascular malformations and other rare diseases. One of cardiomyopathies is arrhythmogenic right ventricle cardiomyopathy or arrhythmogenic dysplasia of right ventricle.

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One of the new directions in study of malignant tumor pathogenesis is telomerase theory. Investigations in the culture of human cells have shown that telomerase activation can lead to tumor development. Prospective investigations of telomerase could be able to supplement the data about tumor pathomorphology and will permit to conduct monitoring on patients with malignant tumors by studying telomerase in fractionated cells from different body tissues and biological media. Telomerase inhibitors are possible drugs for antitumoral therapy. It is supposed that the abovementioned agents will decrease telomerase activity of proliferating tumoral cells that will cause destabilization of their genome, stopping of proliferation and death of tumoral clone.

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