RESUMEN

Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.

Asunto(s)

Aotidae , Infecciones por Campylobacter/inmunología , Campylobacter jejuni/inmunología , Modelos Animales de Enfermedad , Animales , Infecciones por Campylobacter/prevención & control , Diarrea/inmunología , Diarrea/microbiología , Femenino , Inmunización Secundaria , Masculino