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El carcinoma adenoide quístico es una enfermedad muy rara, representando menos del 1% de todos los carcinomas, con alto riesgo de recurrencia local y a distancia. Aunque no disponemos de una conducta terapéutica estándar hasta la fecha, sin embargo, se cuenta con reportes de ser radiosensible. Se presenta el caso de una mujer peruana de 76 años portadora de carcinoma adenoide quístico de cérvix estadio clínico i, manejada inicialmente con histerectomía radical con resultado patológico de carcinoma adenoide quístico asociado a carcinoma adenoide basal, que presentó recurrencia a distancia tempranamente.(AU)

Adenoid cystic carcinoma is a very rare pathology, representing less than 1% of all carcinomas, and has a high risk of local and distant recurrence. Although there is currently no standard management, there are reports of them being radiosensitive. The case is presented of a 76-year-old Peruvian woman with a clinical stage i cervical adenoid cystic carcinoma, specifically managed with radical hysterectomy with a histological result of an adenoid cystic carcinoma associated with basal adenoid carcinoma, presenting with an early distant recurrence.(AU)

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AIMS: The aim of this study was to determine the antiviral activity of four probiotic metabolites (Lactobacillus and Bifidobacetrium species) against rotavirus in vitro infection monitored by the NSP4 protein production and Ca(2+) release. METHODS AND RESULTS: The antiviral effect of the metabolites was performed due a comparison between a blocking model and an intracelullar model on MA104 cells, with the response of NSP4 production and Ca(2+) liberation measured by flow cytometry. Significant results were obtained with the metabolites of Lactobacillus casei, and Bifidobacterium adolescentis in the reduction of the protein production (P = 0·04 and P = 0·014) and Ca(2+) liberation (P = 0·094 and P = 0·020) in the intracellular model, which suggests a successful antiviral activity against RV infection. CONCLUSIONS: This study demonstrates that probiotic metabolites were able to interfere with the final amount of intracellular NSP4 protein and a successful Ca(2+) regulation, which suggests a new approach to the mechanism exerted by probiotics against the rotavirus infection. SIGNIFICANCE AND IMPACT OF THE STUDY: A novel anti-rotaviral effect exerted by probiotic metabolites monitored by the NSP4 protein during the RV in vitro infection and the effect on the Ca(2+) release is reported; suggesting a reduction on the impact of the infection by decreasing the damage of the cells preventing the electrolyte loss.

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The author describes his experience in a Miami hospital, where an average of three to five cases per week of infections to the hand related to intravenous drug abuse were seen. The infections are classified along with the appropriate treatment techniques.

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Six patients with full-thickness skin loss complicating traumatic problems of the hand each had a retrograde forearm fascia flap transfer. Fascial pedicle flaps were used, because more conventional means of coverage had failed or were deemed inappropriate. Four patients had an uncomplicated one-stage flap transfer. Two patients had postoperative hematoma, but no further procedures were required. One patient had superficial necrosis of more than one fourth of the flap. Hematoma and necrosis were considered to be a result of a reversed flow occurring in the radial artery and its vena comitant and to the increased vascular pressure of the flap. This technique provides soft tissue reconstruction of the hand in one stage, with the advantage of early rehabilitation.

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Stable fractures of the metacarpal and proximal phalanges can be treated satisfactorily by closed methods. The problem in those unstable fractures is whether to treat with open or closed reduction. Stiffness of the proximal interphalangeal joint (PIP), malunion, rotation deformities, shortening, and nonunion are known complications of fractures of the proximal phalanx. Fractures at the base of the proximal phalanx. Fractures at the base of the proximal phalanx have low incidence of complications if they are treated closed. Fractures at the shaft carry a much larger risk of complications with either type of treatment. This study of 158 fractures of the proximal phalanx demonstrates that there is a place for conservative treatment in the management of unstable shaft fractures of the proximal phalanx.

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Phialophora richardsiae was discovered in an index finger mass which was thought to be a residual of a steroid injection for tendinitis of the extensor tendon. A case report is presented.

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Closed treatment of hand fractures avoids the stiffness associated with internal fixation. Early motion within the framework described allows the soft tissues to participate in achieving stability of the fracture and seems to speed union.

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PIP: In January 1975 the Population Information Division of the the Population center Foundation in the Philippines began pilot testing a research utilization project in population education. Research utilization began with the identification of problems in population education. Intensive discussions were held in 3 conferences in April, May and June in an effort to elicit a chain of feedback from 4 levels of program professionals. The results of the discussions that occurred during these conferences in a problem-oriented manner are presented in this report. Attention is directed to dealing with 7 problems: 1) should the elementary, the secondary, or the collegiate level receive priority in the implementation of the population education program and how should population education be introduced into the college and high school curricula; 2) case studies to identify the variables which enhance or inhibit population education efforts in different schools and in other institutions; 3) integration has been ineffective because the present scheme of integration is largely dependent on the sequence of content in the mother subject and on the teachers' competence in, and attitudes towards, population education; 4) many teachers trained by the Population Education Program fail to implement population education or are unable to integrate it into the mother subjects when they return to their schools, and this problem is rooted in the training systems; 5) there is a lack of solid research and knowledge base upon which could be drawn the conceptual framework of the population education program; and 6) there is little emphasis on and understanding of value orientation. In addition to problems in the development of the curriculum, discussion is focused on problems in the areas of a method for teaching population education and the introduction of human sexuality into the curriculum.^ieng

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