RESUMEN
Herpesvirus infection is accompanied by imbalance of peripheral mononuclear production of cytokines, by polarizing an immune response by the Th2 pathway. The homozygous TT genotype of T330G polymorphism in the IL-2 gene is an immunogenetic factor that has a protective activity against susceptibility to herpesvirus infection. The risk of progression, the recurrent course of the infection and its poor outcome is positively associated with the heterozygous TG genotype in the IL-2 gene T-330G promoter region and with the homozygous CC type and C allele in the IL-4 gene C-590T promoter region.
Asunto(s)
Alelos , Predisposición Genética a la Enfermedad , Infecciones por Herpesviridae/genética , Interleucina-2/genética , Interleucina-4/genética , Polimorfismo Genético , Adolescente , Adulto , Estudios de Casos y Controles , Femenino , Infecciones por Herpesviridae/inmunología , Infecciones por Herpesviridae/virología , Heterocigoto , Homocigoto , Humanos , Interleucina-2/sangre , Interleucina-4/sangre , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Regiones Promotoras Genéticas , Linfocitos T/inmunología , Adulto JovenRESUMEN
Twenty-five patients (males--11, females--14; aged 18 to 45) with chronic herpes virus infection relapsing at the time of clinical tests were examined, including investigations of the surface architectonics, the ability to blast-transformation and the metabolic status of peripheral-blood lymphocytes. Chronic herpes virus infection was found to be concurrent with changes of the percentage ratio of lymphocytes with the surface micro-patterns of different types, with a more intense activity of the immunity T-chain and with a changed nature of the intracellular metabolism of lymphocyte cells.