RESUMEN
Experimental studies of the mussels hydrolysate (MIGI-K) have shown that this preparation can enhance the radioresistance and general resistance of the organism. The mechanisms of its action are related mainly with its influence on the components of the biochemical back-ground of the resistance and with its antioxidative activity. Some properties of this preparation, for example, absence of toxicity and harmful side effects, made it possible as an adaptogene and as a remedy, increasing radionuclides excretion.
Asunto(s)
Aditivos Alimentarios/uso terapéutico , Centrales Eléctricas , Hidrolisados de Proteína/uso terapéutico , Traumatismos por Radiación/rehabilitación , Protectores contra Radiación/uso terapéutico , Liberación de Radiactividad Peligrosa , Animales , Bivalvos , Humanos , Peroxidación de Lípido/efectos de los fármacos , Peroxidación de Lípido/efectos de la radiación , Megacariocitos/efectos de los fármacos , Megacariocitos/efectos de la radiación , Ratones , Traumatismos por Radiación/sangre , UcraniaRESUMEN
Acid mussel hydrolisate MIGI-K LP is a food product, and a medical and prophylactic preparation containing a full set of irreplaceable amino acids (with the exception of thriptophane), essential fatty acids, macro- and microelements. MIGI-K LP can be used as a foot additive which improves the taste and increases the food qualities of the product, and as a medical preparation against some diseases.
Asunto(s)
Bivalvos/metabolismo , Aditivos Alimentarios/aislamiento & purificación , Depuradores de Radicales Libres/aislamiento & purificación , Hidrolisados de Proteína/aislamiento & purificación , Protectores contra Radiación/aislamiento & purificación , Mariscos , Adolescente , Adulto , Anciano , Aminoácidos/análisis , Animales , Niño , Preescolar , Ácidos Grasos/análisis , Enfermedades Gastrointestinales/dietoterapia , Hepatitis B/dietoterapia , Hepatitis C/dietoterapia , Humanos , Lactante , Persona de Mediana Edad , Control de Calidad , Oligoelementos/análisisRESUMEN
Antiviral properties were found with a preparation obtained from mussel meat by acid hydrolysis. In the experiments in vitro this mussel hydrolysate reduced the infectious activity of influenza viruses in neutralization tests by 3-6 log. Applications of the preparation to mice infected with a toxigenic influenza virus strain protected from death 66-84% of the animals, the survival rate in controls being from 9 to 16%. The protective effect of mussel hydrolysate was observed both after intranasal and oral administrations. The optimal protective effect was obtained when the preparation was used 5-24 hours before inoculation.
Asunto(s)
Antivirales/farmacología , Bivalvos , Carne , Hidrolisados de Proteína/farmacología , Animales , Antivirales/aislamiento & purificación , Antivirales/uso terapéutico , Células Cultivadas , Embrión de Pollo , Depresión Química , Evaluación Preclínica de Medicamentos , Virus de la Influenza A/efectos de los fármacos , Virus de la Influenza B/efectos de los fármacos , Ratones , Infecciones por Orthomyxoviridae/tratamiento farmacológico , Infecciones por Orthomyxoviridae/mortalidad , Hidrolisados de Proteína/aislamiento & purificación , Hidrolisados de Proteína/uso terapéuticoRESUMEN
Irradiation of rats by 131I (10 Gy) incorporated in the thyroid and by 137Cs external source (6 Gy) was made. Part of animals received a ration with Laminaria that reduced a rise in frequency of leukemia, other malignant tumors and increased latent period of tumor formation.
Asunto(s)
Alimentos , Laminaria/fisiología , Leucemia Experimental/prevención & control , Neoplasias Inducidas por Radiación/prevención & control , Animales , Femenino , RatasRESUMEN
The physico-chemical properties of preparation MIGI-K from mussels are given. Some characteristics of melanoidin fractions of MIGI-K are presented, their similarity to standard melanoidin is revealed. The given data on biological activity of the preparation permit to consider MIGI-K as immunomodulator.