RESUMEN
The relationship of serum lipid peroxidation products in hypercholesterolemic subjects to their vitamin E intake was examined in 15 such subjects with no other associated significant disease process in a 3 month trial with vitamin E supplementation. These patients with elevated serum cholesterol levels also have elevated thiobarbituric acid reactive substances (TBARS) and lipid oxidation products (LOPS). Vitamin E supplementation of 800 IU daily normalized the lipid peroxidation products but did not significantly change serum lipids.
Asunto(s)
Hipercolesterolemia/sangre , Hipercolesterolemia/tratamiento farmacológico , Peróxidos Lipídicos/sangre , Vitamina E/uso terapéutico , Adulto , Anciano , Antioxidantes/metabolismo , Carotenoides/sangre , Estudios de Cohortes , Femenino , Humanos , Peroxidación de Lípido , Lípidos/sangre , Masculino , Persona de Mediana Edad , Agregación Plaquetaria/efectos de los fármacos , Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismo , Vitamina E/sangre , beta CarotenoRESUMEN
Previous work in this laboratory had shown in a pilot study that canola oil could lower blood pressure and serum cholesterol levels. Attempting to extend this work to a larger cohort over a longer period, a 4-month study using a 30 ml/day addendum of canola oil as the replacement of the edible oils in the usual diet was undertaken in 36 hypercholesterolemic and/or hypertriglyceridemic subjects. Serum low-density-lipoprotein cholesterol (LDL-C) decreased from 173 +/- 9.0 to 160 +/- 10.0 mg/dl, p less than 0.025. Blood pressure, total cholesterol, and high-density-lipoprotein cholesterol (HDL-C) did not change significantly even though the HDL subfractions did, HDL2 decreasing and HDL3 increasing.