RESUMEN
Primary renal cancinoids are rare, with one hundred cases reported in the literature. Histologically, it is a well-differentiated tumor which shares a morphological pattern similar to that seen in carcinoids identified at other anatomic locations. We report a case of a 45-year-old man with primitive renal carcinoid, with diagnosis made after the detection of liver metastases. The tumour was peculiar given its tubulopapillary architecture, wrongly suggesting a diagnosis of papillary renal carcinoma. This diagnosis was revised 12 years after, following the appearance of other liver, bone and lung metastases.
Asunto(s)
Tumor Carcinoide/patología , Neoplasias Renales/patología , Neoplasias Hepáticas/secundario , Adulto , Neoplasias Óseas/secundario , Tumor Carcinoide/diagnóstico , Carcinoma Papilar/diagnóstico , Humanos , Neoplasias Renales/diagnóstico , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/patología , Neoplasias Pulmonares/secundario , Masculino , Factores de TiempoRESUMEN
BACKGROUND: We examined the association of one linked GC/AT polymorphism at p73 with the risk of colorectal cancer. AIM: In this study, we investigated whether this polymorphism was related to the risk of colorectal cancer, and whether there were relationships between the polymorphism and loss of heterozygosity, protein expression, or clinicopathologic variables. MATERIALS AND METHODS: The p73 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 150 Tunisian patients with colorectal cancer and in 204 healthy control subjects. Immunohistochemistry was performed on normal mucosa, primary tumor, and metastasis. RESULTS: The frequencies of the genotypes were 52% for wild-type (GC/GC), 31% for heterozygotes (GC/AT), and 17% for variants(AT/AT) in patients, and 54%, 35%, and 11% in controls, respectively. There were no significant differences of the frequencies of the 3 genotypes between the patients and controls (P=0.11). We did not find any relationship of the genotypes with clinicopathologic features of patients. We found that patients with the GC/GC genotype had a significantly more favorable clinical outcome than the patients with the AT variants (AT/AT or GC/AT genotype). There were no significant difference between tumoral immunostaining and p73 polymorphism (P=0.16) but we found that the samples carrying the AT allele showed a tendency to be more stained in tumor. No loss of heterozygosity was observed at p73 locus. Our results suggest that the AT/AT genotype is significantly associated with poor prognosis in colorectal cancer. All these findings suggest that p73 polymorphism analysis may provide useful prognostic information for colorectal cancer patients.
Asunto(s)
Neoplasias Colorrectales/genética , Proteínas de Unión al ADN , Inmunohistoquímica , Mucosa Intestinal/ultraestructura , Proteínas Nucleares/genética , Polimorfismo de Longitud del Fragmento de Restricción/genética , Isoformas de Proteínas/genética , Proteínas Supresoras de Tumor , Estudios de Casos y Controles , Neoplasias Colorrectales/mortalidad , Neoplasias Colorrectales/patología , Proteínas de Unión al ADN/genética , Femenino , Estudios de Asociación Genética , Humanos , Inmunohistoquímica/métodos , Mucosa Intestinal/fisiopatología , Estimación de Kaplan-Meier , Pérdida de Heterocigocidad , Masculino , Pronóstico , Estudios Retrospectivos , Factores de Riesgo , Proteína Tumoral p73 , Proteínas Supresoras de Tumor/genética , TúnezRESUMEN
AIM: to study the clinicopathological features of the different types of appendical mucocele and to compare them with those of pseudomyxoma peritonei. METHODS: 25 cases of appendical mucocele were operated in the Cap-Bon region in Tunisia during a period of 13 years from 1994 to 2006. RESULTS: 9 retentionnal cysts, 13 mucinous cystadenomas, one serrated adenoma, one hyperplasia of the mucosa and one cystadenocarcinoma were diagnosed. Five cystadenomas as well as the only case of cystadenocarcinoma were associated with pseudomyxoma peritonei. Pseudomyxoma peritonei occurred 20 years later than in simple appendiceal mucocèle and complicated 5 cases of cystadenoma with low grade dysplasia and 1 case of cystadenocarcinoma. CONCLUSION: Preoperative diagnosis of appendical mucocele and pseudomyxoma peritonei should be made on scannographic features in order to assess the adequate surgical management.