Asunto(s)
Enfermedades Autoinmunes/terapia , Púrpura Trombocitopénica Idiopática/terapia , Adulto , Examen de la Médula Ósea , Niño , Ensayos Clínicos como Asunto , Terapia Combinada , Urgencias Médicas , Femenino , Glucocorticoides/uso terapéutico , Hemorragia/etiología , Hemorragia/prevención & control , Hospitalización , Humanos , Inmunidad Materno-Adquirida , Inmunoglobulinas Intravenosas/uso terapéutico , Inmunosupresores/uso terapéutico , Recién Nacido , Masculino , Recuento de Plaquetas , Embarazo , Complicaciones Hematológicas del Embarazo/diagnóstico , Complicaciones Hematológicas del Embarazo/terapia , Púrpura Trombocitopénica Idiopática/complicaciones , Púrpura Trombocitopénica Idiopática/congénito , Púrpura Trombocitopénica Idiopática/diagnóstico , Globulina Inmune rho(D)/uso terapéutico , Esplenectomía , Resultado del TratamientoRESUMEN
Interleukin-1 (IL-1) bioassays were done on 208 serum samples drawn from 7 volunteers, over several hours at 5-minute intervals, before, during, and after a relaxation-related behavioral stimulus. Individuals showed up to a 267% increase (t[29] = 7.750, p = 1 x 10(-7).) in IL-1, and for the group, a mean 48.1% elevation (t[5] = 4.128, p = .003) occurred, during the stimulus interval relative to baseline. When baselines were repeated, IL-1 activity rapidly returned toward baseline values. Suggestions to picture one's immune cells fighting illness appeared to have no uniform effect for all subjects. Such rapid changes in plasma IL-1, concomitant with stimuli, indicate a new way to alter immune function and further understand disease susceptibility.
Asunto(s)
Nivel de Alerta/fisiología , Interleucina-1/sangre , Terapia por Relajación , Adulto , Electromiografía , Femenino , Humanos , Imaginación/fisiología , Masculino , Persona de Mediana Edad , Solución de Problemas/fisiología , Psiconeuroinmunología , Respiración/fisiología , Temperatura Cutánea/fisiologíaRESUMEN
The occurrence of Kaposi's sarcoma in young homosexual men is a recently reported condition. The same individuals are at risk for the development of Pneumocystis carinii pneumonia and other unusual infections. These associations suggest these persons are somehow immunocompromised. Evidence of current or prior cytomegalovirus (CMV) infection is seen in a high percentage of these and other homosexual men. CMV infections are known to induce alterations in the immunoregulatory suppressor and helper T lymphocyte populations. The CMV infection is suspect as the cause of immunosuppression in these individuals. We present a case of Kaposi's sarcoma in a homosexual men with CMV cultured from his urine and semen. He showed a marked increase in his suppressor/cytotoxic cell (OKT8-positive) population, as well as a marked decrease in his helper cell (OKT4-positive) population. Mitogen and antigen studies demonstrated absent or markedly diminished response both in vitro and in vivo. Pokeweed mitogen (PWM)-induced IgG synthesis appeared normal. This patient, as well as the majority of other reported patients with this disease, manifested the HLA-Dr5 phenotype. The immunosuppression in this patient and possibly other similar men appears to be mediated by abnormalities in the immunoregulatory T lymphocytes.
Asunto(s)
Homosexualidad , Tolerancia Inmunológica , Neoplasias del Recto/inmunología , Sarcoma de Kaposi/inmunología , Neoplasias Cutáneas/inmunología , Adulto , Anticuerpos Monoclonales/inmunología , Citomegalovirus/inmunología , Antígeno HLA-DR5 , Antígenos de Histocompatibilidad Clase II/inmunología , Humanos , Masculino , Mitógenos de Phytolacca americana/inmunología , Linfocitos T/inmunologíaRESUMEN
PIP: Presented in this essay are suggestions for rewriting Roe vs. Wade, the case that resulted in the establishment of a constitutional right to abortion. Essentially, the argument is 1 of equal protection. It is suggested that abortion be viewed as presenting a problem that might be termed "the law of samaritanism" -- the law regarding obligations imposed on certain individuals to provide assistance to others. In American law it is a deeply rooted principle that an individual is ordinarily not required to volunteer assistance to another individual who is in danger or in need of aid. The argument presented maintains that if a pregnant woman is required to carry the fetus to term and deliver it, then she is being compelled to be a Good Samaritan. It is argued further that if the generally limited scope of obligations of samaritanism under current law are considered, and the special nature of the burdens imposed on pregnant women by laws forbidding abortion are also considered, the obvious conclusion is that the equal protection clause forbids imposition of these burdens on pregnant women. The argument is developed in a lengthy form and calls for an extended discussion of the law of samaritanism. The uniqueness of the abortion case also creates problems as the equal protection argument is approached, and an approach to equal protection questions is sketched.^ieng
Asunto(s)
Aborto Legal/tendencias , Mujeres Embarazadas , Derechos de la Mujer/legislación & jurisprudencia , Femenino , Humanos , Obligaciones Morales , Embarazo , Decisiones de la Corte Suprema , Estados UnidosAsunto(s)
Modelos Biológicos , Factor de Transferencia , Fosfatasa Alcalina/farmacología , Carboxipeptidasas/farmacología , Fenómenos Químicos , Química , Cromatografía en Gel , Coccidioidina/inmunología , Exonucleasas/farmacología , Hemocianinas/inmunología , Humanos , Inosina , Inosina Monofosfato , Leucaféresis , Péptidos , Fitohemaglutininas/farmacología , Pruebas CutáneasAsunto(s)
Envejecimiento Eritrocítico , Eritrocitos/metabolismo , Ácidos Siálicos/metabolismo , Adulto , Aspartato Aminotransferasas/metabolismo , Fraccionamiento Celular , Electroforesis , Recuento de Eritrocitos , Membrana Eritrocítica/metabolismo , Eritrocitos/enzimología , Humanos , Propiedades de SuperficieRESUMEN
L-Asparaginase (EC 3.5.1.1) inhibited respiration in sensitive, but not resistant, lines of murine lymphoma 6C3HED. Glucose, in these tumor lines, was principally converted to lactate, and very little was oxidized in the citric acid cycle or hexose monophosphate shunt. The cells derived 70-80% of their respiratory CO(2) from glutamine or glutamate. Asparaginase had no effect on the pattern of glucose utilization. The differential effect on oxygen consumption may result from the absence of asparagine synthetase in sensitive cells. Respiration may be inhibited by accumulation of the aspartate, the product of glutamate oxidation. Resistant lymphoma cells remove aspartate by converting it to asparagine. Sensitive cells, which lack asparagine synthetase, cannot make asparagine.