RESUMEN
Two-solution bone cements modified with ethylene glycol-dimethacrylate (EG-DMA) as a crosslinker have been developed as an attempt to further improve the mechanical properties of acrylic bone cement. The result of this study shows that EG-DMA can increase the mechanical properties and fractional monomer conversion while preserving the thermal characteristics. The strength and bending modulus increase with EG-DMA concentrations at 5-10 vol % EG-DMA. Substituting the EG-DMA content past 10 vol % decreases the bending properties due to the effects of reduced monomer concentrations. Strengthened EG-DMA samples demonstrated an increase in ductility with noticeably different fracture surface morphologies than the control samples, indicated by microtroughs and ridge formation caused by excessive plastic strain. This work provides insight into the effect of substituting a crosslinker for MMA monomer in an injectable two-solution system and lays out the ideal concentrations of EG-DMA for superior mechanical or fractional monomer conversion properties. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part B, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 783-790, 2019.
Asunto(s)
Cementos para Huesos/química , Reactivos de Enlaces Cruzados/química , Ensayo de Materiales , Metacrilatos/química , Polimetil Metacrilato/química , Estrés MecánicoRESUMEN
Excitation energy transfer (EET) determines the fate of sunlight energy absorbed by light-harvesting proteins in natural photosynthetic systems and photovoltaic cells. As previously reported (D. Kosenkov, J. Comput. Chem. 2016, 37(19), 1847), PyFREC software enables computation of electronic couplings between organic molecules with a molecular fragmentation approach. The present work reports implementation of direct fragmentation-based computation of the electronic couplings and EET rates in pigment-protein complexes within the Förster theory in PyFREC. The new feature enables assessment of EET pathways in a wide range of photosynthetic complexes, as well as artificial molecular architectures that include light-harvesting proteins or tagged fluorescent biomolecules. The developed methodology has been tested analyzing EET in the Fenna-Matthews-Olson (FMO) pigment-protein complex. The pathways of excitation energy transfer in FMO have been identified based on the kinetics studies. © 2017 Wiley Periodicals, Inc.
Asunto(s)
Transferencia de Energía , Complejos de Proteína Captadores de Luz/química , Complejos de Proteína Captadores de Luz/metabolismo , Simulación de Dinámica Molecular , Teoría Cuántica , CinéticaRESUMEN
Hereditary angioedema attacks are rare, but emergency care providers must be aware of the clinical presentation and treatment of these patients because the emergency department remains the most common setting where these patients seek treatment. If providers are not aware of the past medical history of these patients, they are likely to receive standard therapies for respiratory distress and anaphylaxis including antihistamines, corticosteroids, and epinephrine. However, these medications may not work in these patients, given the pathophysiology of their underlying disease. Since 2009, several new therapies have been approved for the treatment of acute hereditary angioedema attacks. This article discusses pathophysiology, clinical presentation, and use of novel therapies for the management of angioedema.
Asunto(s)
Angioedemas Hereditarios/tratamiento farmacológico , Proteínas Inactivadoras del Complemento 1/uso terapéutico , Corticoesteroides/uso terapéutico , Angioedemas Hereditarios/diagnóstico , Angioedemas Hereditarios/fisiopatología , Servicio de Urgencia en Hospital , Epinefrina/uso terapéutico , Antagonistas de los Receptores Histamínicos/uso terapéutico , Humanos , PlasmaRESUMEN
Health care providers in the emergency department (ED) frequently find themselves caring for patients who may have overdosed on a medication(s) or other toxic substance. These patients can prove to be a challenge, as providers must try to determine the substance(s) involved so that the appropriate treatment can be initiated. For those patients who are hemodynamically unstable upon presentation, it is important to note that supportive care is of the utmost importance, as there are few substances that have antidotes available. In these situations, lipid emulsion can be considered. This is especially true in the setting of the following toxicities: local anesthetics, ß-blockers, calcium channel blockers, and the tricyclic antidepressants. Even though lipid emulsion may not be used that frequently in the ED, it is important to be aware of its role in the setting of toxicological emergencies, how it should be dosed and administered, and the necessary safety precautions.