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1.
J Cosmet Dermatol ; 17(1): 105-111, 2018 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28504468

RESUMEN

OBJECTIVES: To determine whether the oxidative stress transmitted to newly grown hair from an unhealthy scalp has physical consequences to the cuticular condition and function. METHODS: A uniquely designed 24-week clinical study included 8 weeks of pretreatment with a cosmetic shampoo and 16 weeks of treatment with either a potentiated zinc pyrithione (ZPT) antidandruff shampoo or a placebo cosmetic shampoo. This clinical design allowed the growth and acquisition of hair samples under conditions of varying but known scalp health as a result of treating a dandruff/seborrheic dermatitis (D/SD) population. Two complementary methods were used to characterize the integrity of the cuticular surface. Hair surface hydrophobicity was assessed by quantifying water wetting force using a Wilhelmy balance method. Surface structure and porosity were assessed using dynamic vapor sorption (DVS) to gravimetrically quantify water sorption. RESULTS: Chemical oxidative stress to pre-emergent hair has been shown to have negative consequences to hair surface structure. Compared to a placebo shampoo control, use of a potentiated ZPT shampoo improved scalp health and significantly improved the following attributes associated with healthy hair: hair surface hydrophobicity (surface energy) and cuticular moisture barrier effectiveness (dynamic vapor sorption). CONCLUSIONS: Pre-emergent hair can be negatively impacted by the oxidative stress that occurs with an unhealthy scalp, possibly due to metabolic activity of resident microbes. Manifestations of the oxidative stress include altered cuticle surface properties that are responsible for its protective function; these effects are similar in type to those observed by bleaching post-emergent hair. These alterations have the potential to make the hair, once emerged from the scalp, more susceptible to the cumulative physical and chemical insults responsible for hair feel and look, fiber integrity, and overall retention.


Asunto(s)
Caspa/terapia , Dermatitis Seborreica/terapia , Preparaciones para el Cabello/uso terapéutico , Compuestos Organometálicos/uso terapéutico , Estrés Oxidativo/fisiología , Piridinas/uso terapéutico , Dermatosis del Cuero Cabelludo/terapia , Adolescente , Adulto , Anciano , Canadá , Dermatitis Seborreica/fisiopatología , Método Doble Ciego , Femenino , Folículo Piloso/efectos de los fármacos , Preparaciones para el Cabello/química , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Medición de Riesgo , Dermatosis del Cuero Cabelludo/fisiopatología , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Adulto Joven
2.
Int J Pharm ; 339(1-2): 175-88, 2007 Jul 18.
Artículo en Inglés | MEDLINE | ID: mdl-17433585

RESUMEN

High efficiency in polymorph screening and crystallization optimization can be gained by judicious selection of solvents for the study design. Examination of all 57 (classes 2 and 3) pharmaceutical solvents may enable a complete study design but is costly in terms of time and resources. Based on a 17 descriptor dataset specifically constructed for all the classes 2 and 3 pharmaceutical solvents recognized by the International Conference of Harmonization (ICH), an optimal two-stage cluster analysis was carried out together with principal component analysis as a dimensionality and colinearity reduction pre-processor. Both hierarchical average linkage cluster analysis and non-hierarchical K-means cluster analysis converged on a 20-cluster solution with strong statistical criteria support and excellent agreement in cluster memberships, which can be reasonably interpreted from a chemical perspective. This 20-cluster solution is offered as an option for design of more efficient solid state screening studies. Rather than designing a polymorph screen to include all 57 solvents, the inclusion of a single member from each of the 20 clusters would be expected to adequately represent the full range of solvent properties exhibited by the entire 57 member solvent set.


Asunto(s)
Solventes/clasificación , Análisis por Conglomerados , Proyectos de Investigación , Solventes/química
3.
J Pharm Sci ; 95(12): 2631-44, 2006 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-16917848

RESUMEN

Dehydration of hydrates of pharmaceutical active ingredients (pharmaceutical hydrates) may easily occur during storage or manufacturing. Loss of water may have little effect on the crystal lattice, produce less hydrated forms or possibly amorphous forms. Characterizing the effects of water loss on crystal hydrate forms is important for understanding the behavior of pharmaceutical hydrates throughout the manufacturing and storage processes. This study shows that exposure of the hemi-pentahydrate form of risedronate monosodium to gentle heating (60 degrees C) or conditions of low relative humidity (<10% RH) results in the loss of 1 mole of channel-type water. Upon removal of the channel-type water, the crystal lattice adjusts producing a distinct phase characterized by X-ray, thermal, IR, Raman, and NMR data. Adjustment of the crystal lattice appears to compromise crystal integrity and can result in reduced crystallite and particle sizes.


Asunto(s)
Conservadores de la Densidad Ósea/química , Ácido Etidrónico/análogos & derivados , Agua/química , Rastreo Diferencial de Calorimetría , Cristalización , Desecación , Composición de Medicamentos , Ácido Etidrónico/química , Calor , Espectroscopía de Resonancia Magnética , Tamaño de la Partícula , Ácido Risedrónico , Espectroscopía Infrarroja por Transformada de Fourier , Espectrometría Raman , Termogravimetría , Difracción de Rayos X
4.
J Pharm Sci ; 94(4): 893-911, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15736193

RESUMEN

Four hydration states are reported for Risedronate monosodium. A single-crystal X-ray structure determination is provided as proof of assignment for the monohydrate, hemi-pentahydrate, and variable hydrate forms. The structure provided for the anhydrate form was determined through simulating annealing calculations and subsequent Reitveld refinement of a high-quality X-ray powder diffraction patterns Favorable comparisons of experimentally obtained X-ray powder patterns are made to those generated from the single crystal data. Characteristic infrared, Raman, and NMR spectra are provided and discussed for each form as are thermal analysis profiles. In addition, photomicrographs are provided for each of the forms isolated for this study. The hemi-pentahydrate is demonstrated to be the equilibrium form at room temperature and 37 degrees C, in the presence of water.


Asunto(s)
Ácido Etidrónico/análogos & derivados , Ácido Etidrónico/química , Absorción , Cristalografía por Rayos X , Análisis Diferencial Térmico , Excipientes , Espectroscopía de Resonancia Magnética , Modelos Moleculares , Ácido Risedrónico , Espectrofotometría Infrarroja , Espectroscopía Infrarroja por Transformada de Fourier , Espectrometría Raman
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