RESUMEN
Chronic cutaneous lupus erythematosus is a polymorphous autoimmune disease which may mimic some other clinical conditions, causing diagnostic difficulties. Acneiform lesions, including comedones and pitting scars are occasionally atypical presentations of cutaneous discoid lupus erythematosus.
Asunto(s)
Dermatosis Facial/patología , Lupus Eritematoso Discoide/patología , Adulto , Antibacterianos/uso terapéutico , Enfermedad Crónica , Dermatosis Facial/tratamiento farmacológico , Femenino , Humanos , Hidroxicloroquina/uso terapéutico , Lupus Eritematoso Discoide/tratamiento farmacológico , Tetraciclina/uso terapéuticoRESUMEN
An 83 year old woman, exhibiting severe psoriasis, was treated conventionally (phototherapy, acitretin, and cyclosporine). After poor clinical results and significant changes in laboratory procedures, those treatments were suspended. She was then being prepared to be submitted to biological treatment, when preliminary results disclosed a 30 mm PPD. Complete improvement occurred [only] after introducing prophylactic therapy for tuberculosis and anti-depressive medication.
Asunto(s)
Antidepresivos/uso terapéutico , Trastorno Depresivo/tratamiento farmacológico , Psoriasis/tratamiento farmacológico , Sertralina/uso terapéutico , Anciano de 80 o más Años , Antituberculosos/uso terapéutico , Trastorno Depresivo/complicaciones , Femenino , Humanos , Quimioterapia de Inducción/métodos , Isoniazida/uso terapéutico , Masculino , Psoriasis/etiología , Tuberculosis Cutánea/tratamiento farmacológico , Tuberculosis Cutánea/etiologíaRESUMEN
Lúpus eritematoso cutâneo crônico é doença autoimune, com apresentações polimorfas que podem, eventualmente, mimetizar outras condições clínicas, causando dificuldade diagnóstica. Quadro acneiforme, com comedões e lesões atróficas pontuadas (pitting scars) pode constituir apresentação atípica do lúpus eritematoso cutâneo discóide.
Chronic cutaneous lupus erythematosus is a polymorphous autoimmune disease which may mimic some other clinical conditions, causing diagnostic difficulties. Acneiform lesions, including comedones and pitting scars are occasionally atypical presentations of cutaneous discoid lupus erythematosus.
Asunto(s)
Adulto , Femenino , Humanos , Dermatosis Facial/patología , Lupus Eritematoso Discoide/patología , Antibacterianos/uso terapéutico , Enfermedad Crónica , Dermatosis Facial/tratamiento farmacológico , Hidroxicloroquina/uso terapéutico , Lupus Eritematoso Discoide/tratamiento farmacológico , Tetraciclina/uso terapéuticoRESUMEN
Mulher idosa apresentou psoríase em placas do tipo grave, com tendência eritrodérmica, e foi submetida a tratamento de acordo com o algoritmo consensual (fototerapia, acitretina, ciclosporina). Resultados clínicos insuficientes, recorrência e agravamento do quadro laboratorial orientaram no sentido da introdução de terapia biológica. A avaliação preliminar revelou PPD de 30mm. A resolução completa das lesões se verificou quando realizada profilaxia antituberculose e administrado antidepressivo.
An 83 year old woman, exhibiting severe psoriasis, was treated conventionally (phototherapy, acitretin, and cyclosporine). After poor clinical results and significant changes in laboratory procedures, those treatments were suspended. She was then being prepared to be submitted to biological treatment, when preliminary results disclosed a 30mm PPD. Complete improvement occurred [only] after introducing prophylactic therapy for tuberculosis and anti-depressive medication.
Asunto(s)
Anciano de 80 o más Años , Femenino , Humanos , Masculino , Antidepresivos/uso terapéutico , Trastorno Depresivo/tratamiento farmacológico , Psoriasis/tratamiento farmacológico , Sertralina/uso terapéutico , Antituberculosos/uso terapéutico , Trastorno Depresivo/complicaciones , Quimioterapia de Inducción/métodos , Isoniazida/uso terapéutico , Psoriasis/etiología , Tuberculosis Cutánea/tratamiento farmacológico , Tuberculosis Cutánea/etiologíaRESUMEN
Langerhans cell histiocytosis is defined as a clonal proliferation of Langerhans phenotypic-like cells. Letterer-Siwe disease is the most common and serious of these entities, affecting mainly infants up to two years of age. We present two cases of this rare disease, diagnosed after dermatological examination, highlighting its typical aspects.
Asunto(s)
Histiocitosis de Células de Langerhans , Histiocitosis de Células de Langerhans/patología , Humanos , Lactante , MasculinoRESUMEN
A histiocitose de células de Langerhans é proliferação clonal de células fenotipicamente semelhantes às células de Langerhans. Anteriormente denominada Letterer-Siwe, é a forma mais comum e mais grave dessa enfermidade, acometendo sobretudo crianças até os dois anos de idade. São apresentados dois casos dessa rara doença, diagnosticados após parecer dermatológico, destacando-se seus aspectos mais característicos.
Langerhans cell histiocytosis is defined as a clonal proliferation of Langerhans phenotypic-like cells. Letterer-Siwe disease is the most common and serious of these entities, affecting mainly infants up to two years of age. We present two cases of this rare disease, diagnosed after dermatological examination, highligthing its typical aspects.