RESUMEN

The first non-chiral pool total synthesis of (+)-hyacinthacine A(1) is described. This synthesis is based on an effective [2 + 2] cycloaddition of dichloroketene to a Stericol-based enol ether, a diastereoselective dihydroxylation, and an efficient Tamao-Fleming oxidation.

Asunto(s)

Alcaloides de Pirrolicidina/síntesis química , Ciclización , Dicloroetilenos/química , Estructura Molecular , Alcaloides de Pirrolicidina/química , Estereoisomerismo