RESUMEN
In the title compound, C20H18ClN3O3, the five- and six-membered heterocycles fused through a spiro C atom are inclined to each other at an angle of 87.4â (1)°. In the tricyclic ring system, the cyclo-hexene ring adopts an envelope conformation with the spiro atom as the flap. In the crystal, two sets of N-Hâ¯O hydrogen bonds link the mol-ecules into columns containing centrosymmetric R 2 (2)(7) ring motifs and propagating along the b-axis direction.
RESUMEN
Towards the development of new biomaterials for use in angioplasty, star-shaped polylactic acids have been synthesised and shown to adhere well to living cells, by in vitro and in vivo experiments, and to hydrolyse over time in a physiologically relevant environment into biocompatible and bioabsorbable entities that are capable of bestowing properties of anticoagulation and angiogenesis to their living host.
RESUMEN
In the title compound, C41H32N6O2S, the pyrrolo-thia-zole ring system is folded about the bridging N-C bond. The thia-zolidine and pyrrolidine rings adopt envelope (with the fused C atom as the flap) and twisted conformations, respectively. The two phenyl rings attached to the pyrazole ring are twisted from the plane of the latter by 6.8â (1) and 52.8â (1)°. The allyl group is disordered over two conformations in a 0.805â (6):0.195â (6) ratio. In the crystal, pairs of N-Hâ¯O hydrogen bonds link the mol-ecules into centrosymmetric dimers.
RESUMEN
In the title compound, C27H19ClFN3O3, the pyrazole ring has a twist conformation and the six-membered ring to which it is fused has a screw-boat conformation. The mean plane of the pyrazole ring is inclined to the 2-methyl-indoline ring by 85.03â (9) and by 28.17â (8)° to the mean plane of the iso-quinoline ring system. In the crystal, mol-ecules are linked by pairs of C-Hâ¯F hydrogen bonds, forming inversion dimers. These dimers are linked via C-Hâ¯O hydrogen bonds, forming a two-dimensional network lying parallel to (10-1).
RESUMEN
In the title compound, C22H20ClN3O4, the central pyrrolidine ring adopts an envelope conformation on the N atom. The indolinone systems are individually roughly planar, with maximum deviations from their mean planes of 0.130â Å for the spiro C atom of the indolinone unit and 0.172â Å for the carbonyl C atom of the 5-chloro-1-methyl-indolinone unit. They make dihedral angles of 77.7â (8) and 86.1â (8)° with the mean plane through the central pyrrolidine ring. In the crystal, mol-ecules are linked by N-Hâ¯O hydrogen bonds supported by C-Hâ¯O contacts into chains along the ab diagonal. The structure also features C-Hâ¯O hydrogen bonds, forming R 2 (2)(8) and R 2 (2)(16) rings and generating a three-dimensional array.
RESUMEN
In the title compound, C26H22N2O4, the central pyrrolidine ring adopts a twist conformation and the cyclo-pentane ring of the dihydro-acenapthylene group adopts an envelope conformation with the spiro C atom as the flap. The naphthalene ring system of the dihydro-acenaphthyl-ene group forms dihedral angles of 83.4â (9) and 61.3â (7)°, respectively, with the mean planes of the pyrrolidine and indole rings. The crystal packing is stabilized by inter-molecular C-Hâ¯O hydrogen bonds. The title compound is a diastereomer of a previously reported structure.