RESUMEN

A cyclic peptide, jatrophidin I, was isolated from the latex of Jatropha curcas L. Its structure was elucidated by extensive 2D NMR spectroscopic analysis, with additional conformational studies performed using Molecular Dynamics/Simulated Annealing (MD/SA). Jatrophidin I had moderate protease inhibition activity when compared with pepstatin A; however, the peptide was inactive in antimalarial, cytotoxic and antioxidant assays.

Asunto(s)

Jatropha/química , Látex/química , Péptidos Cíclicos/aislamiento & purificación , Proteasas de Ácido Aspártico/antagonistas & inhibidores , Brasil , Ensayos de Selección de Medicamentos Antitumorales , Modelos Moleculares , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Pepstatinas/farmacología , Péptidos Cíclicos/química , Péptidos Cíclicos/farmacología