RESUMEN
The authors studied the content of gonadotropins and testosterone in the blood; functional condition of the hypothalamus-hypophysis-ovarian system was characterized in patients with ovarian hyperandrogenia by using the klomiphen test. Testosterone level in all the patients and prolactin level in 70% of the patients proved to exceed the normal values, wheras the LH level could be low, normal or high. With klomiphen test it was shown that both the gonadotropin and estrogen levels rose against the background of action of the preparation; as to testosterone level--it remained unchanged. In induced menstrual cycles estradiol peak preceded the gonadotropin peak. In patients with ovulation testosterone level diminished by the end of the observation period.
Asunto(s)
Andrógenos/sangre , Clomifeno , Hipotálamo/fisiopatología , Pruebas de Función Ovárica , Hipófisis/fisiopatología , Síndrome del Ovario Poliquístico/fisiopatología , Adolescente , Adulto , Estradiol/sangre , Femenino , Hormona Folículo Estimulante/sangre , Humanos , Hormona Luteinizante/sangre , Ovario/fisiopatología , Pruebas de Función Hipofisaria , Prolactina/sangre , Testosterona/sangreAsunto(s)
Enfermedades de la Corteza Suprarrenal/congénito , Corticoesteroides/metabolismo , Corteza Suprarrenal/fisiopatología , Enfermedades de las Glándulas Suprarrenales/congénito , Ritmo Circadiano , Testosterona/metabolismo , Adolescente , Enfermedades de la Corteza Suprarrenal/fisiopatología , Niño , Femenino , HumanosRESUMEN
PIP: The affinity of 2C(19)-steroids, 11C(18)-steroids, 5-11-N-C(17)-steroids and 2C(21)-steroids to testosterone-estradiol-binding globulin (TSEG) of the retroplacental human plasma was studied. It was found that the required condition for the active binding of synthetic steroids of the C(18) series is the presence of the 17-hydroxyl group and of the oxygen function of the 3rd position of the A-ring. The greatest affinity to TSEG was shown by testosterone, estradiol, and its methylester.^ieng