1.
Chem Commun (Camb)
; 60(14): 1928-1931, 2024 Feb 13.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38268331
RESUMEN
Developing new chemotherapeutics that are structurally and mechanistically unique is needed due to the rapid rise of the cancer incidence across the globe. Here, we report the identification of irreversible, thiol-reactive diazepam derivatives as GPX4 modifiers and nanomolar inducers of ferroptosis in liver cancer cells.
Asunto(s)
Ferroptosis , Neoplasias Hepáticas , Humanos , Línea Celular , Diazepam , Compuestos de Sulfhidrilo , Neoplasias Hepáticas/tratamiento farmacológico
2.
Chem Commun (Camb)
; 58(83): 11669-11672, 2022 Oct 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36172810
RESUMEN
Antimicrobial resistance (AMR) is a global health concern. Targetting AMR, we present an in situ lactonization mechanism generating 4-nitroisobenzofuran-1(3H)-one (IITK2020), an exclusive S. aureus inhibitor at 2-4 µg mL-1 MIC including multidrug-resistant S. aureus clinical strains, that prevents peptidoglycan biosynthesis.