RESUMEN

The nuclear receptor coactivator 5 (NCOA5) has been linked to several inflammatory disorders, including Behçet's disease (BD). We evaluated the expression of NCOA5 messenger RNA (mRNA) using real-time reverse transcription-polymerase chain reaction, and analyzed the rs2903908 T > C of NCOA5 using TaqMan allelic discrimination assay in 49 Egyptian BD patients and 50 controls. The NCOA5 mRNA levels were higher in patients compared to controls (p = .02), female patients compared to males (p = .037), and in patients with ocular involvement (p = .049). Non-CC genotype carriers had a higher frequency of articular manifestations compared with CC carriers (p = .047). Genotypes CC + CT were associated with reduced risk of cutaneous involvement (OR = 0.27, p = .04). CC carriers with active BD or cutaneous manifestations displayed significantly lower NCOA5 mRNA expression than TT carriers. Our results demonstrate that NCOA5 is linked to BD clinical findings and activity.

Asunto(s)

Síndrome de Behçet , Coactivadores de Receptor Nuclear , Polimorfismo de Nucleótido Simple , Femenino , Humanos , Masculino , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/genética , Estudios de Casos y Controles , Egipto/epidemiología , Frecuencia de los Genes , Predisposición Genética a la Enfermedad , Genotipo , Coactivadores de Receptor Nuclear/genética , Coactivadores de Receptor Nuclear/metabolismo , ARN Mensajero/genética , ARN Mensajero/metabolismo