Asunto(s)
Neoplasias Óseas , Hemangioendotelioma Epitelioide , Hueso Esfenoides/patología , Adulto , Antígenos CD34/metabolismo , Neoplasias Óseas/diagnóstico , Neoplasias Óseas/metabolismo , Femenino , Hemangioendotelioma Epitelioide/diagnóstico , Hemangioendotelioma Epitelioide/metabolismo , Humanos , Imagen por Resonancia Magnética , Proteínas de Microfilamentos/metabolismo , Mucina-1/metabolismo , Molécula-1 de Adhesión Celular Endotelial de Plaqueta/metabolismo , Receptores Citoplasmáticos y Nucleares/metabolismo , Tomógrafos Computarizados por Rayos X , TransactivadoresRESUMEN
ortho-Acylation attempt of benzenesulfonamide afforded the corresponding hemiaminal as major product. The in situ reduction of the reaction mixture, reported herein, directly provided 2-hydroxyalkyl benzenesulfonamide, an important pharmacophoric element for designing drug-like scaffolds. Its application is demonstrated through designing a novel series of 1,5-diarylpyrazoles for cyclooxygenase-2 (COX-2) inhibition.
Asunto(s)
Aldehídos/química , Alcanos/química , Sulfonamidas/química , Ácido gamma-Aminobutírico , Inhibidores de Anhidrasa Carbónica/química , Química Farmacéutica , Diseño de Fármacos , Modelos Moleculares , Estructura Molecular , Oxidación-Reducción , BencenosulfonamidasRESUMEN
An investigation of the chemistry of ginkgolides A, B and C (1) has revealed an unusual interaction between the hydroxyl groups at C(1) and C(10) which activates their deprotonation to give 2 and provides a method for the interconversion of 1C and 1B. The ginkgolide 7-enol system 7 is more stable than the corresponding 7-keto form 6, which is easily made by selective Jones oxidation of ginkgolide C.