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This article examines traditions of testing drugs (as substances) and trying cures (on patients) in medieval and early modern Europe. It argues that the history of drug testing needs to be a more central story to overall histories of scientific experiment. The practice of conducting thoughtful-and sometimes contrived-tests on drugs has a rich and varied tradition dating back to antiquity, which expanded in the Middle Ages and early modern period. Learned physicians paired text-based knowledge (reason) with hands-on testing (experience or experiment) in order to make claims about drugs' properties or effects on humans. Lay practitioners similarly used hands-on testing to gain knowledge of pharmaceutical effects. Although drug testing practices expanded in scale, actors, and sites, therpublished a work extolling the virtues of drugs froe was significant continuity from the Middle Ages to the eighteenth century.

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This article describes the use of poison trials, in which an animal or a condemned criminal was poisoned, to test antidotes in sixteenth-century Europe. In contrast to most drug testing in medieval and early modern Europe, which was gathered in the normal course of therapeutic experience, the poison trial was a contrived, deliberate event. I argue that poison trials had an important function in both medical testing and medical writing in the period between 1524-1580. While poison trials dated back to antiquity, they tended to be described in medieval texts as theoretical possibilities rather than empirical tests that had already occurred. In contrast, early modern physicians conducted poison trials and described them as anecdotes in medical texts. Although physicians did not explicitly separate poison trials from evidence gathered in the course of regular therapeutic experience, they did imbue the outcome of poison trials with considerable epistemological weight.

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This essay examines the conflicting approaches towards marvelous cures in sixteenth-century Germany As pharmaceutical substances flooded in from both east and west, they brought with them a market for "wonder drugs" that would cure any ailment. In this climate, university-trained physicians felt threatened by the rising popularity of cures hawked by empirical practitioners, while at the same time endorsing certain wonder drugs. Using the example of one particularly controversial empiric, Georg am Wald, and his wonder drug, the Panacea Amwaldina, this article parses the various factors that made the medical elite embrace certain cures while deriding others.

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This article uses the case of German noblewoman Elisabeth of Rochlitz as a window on sixteenth-century patient attitudes toward disease and the body. A widowed duchess of Saxony, Elisabeth spent the last twenty years of her life battling an increasingly serious string of illnesses. Despite her ready access to learned physicians and her friendly relationship with several of them, she used a wide variety of practitioners and frequently privileged lower-status healers when she perceived their methods to be more efficacious. She placed the greatest weight on remedies that would relieve the experienced symptoms of her illness, rather than more holistic methods such as doctors' regimens. This perception of disease as a set of symptoms led to a dispute about the meaning of signs in her final illness.

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This essay proposes that the well-documented interest in empirical and experimental practice at the early modern German courts was not limited to male practitioners. Just as princes evinced an interest in practical alchemy, mathematics, and astronomy, a large number of gentlewomen became expert medical practitioners. Using a case study of one noblewoman, Electress Anna of Saxony, I would like to expand the notion of "prince-practitioning" to a more general and inclusive "court experimentalism." Like the prince-practitioners, Anna engaged in a laborious attempt to learn the hands-on techniques involved in becoming an expert; she collaborated with both noblewomen and noblemen in her efforts; and she semantically linked her medicine to the alchemical skills (Künste) practiced by her husband, Elector August. Although court experimentalism cannot be equated with experimentation in the modern sense, medicine is one area in which women actively shared in the early modern fascination with empirical knowledge.

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