RESUMEN
We showed for the first time that polymorphisms rs2075938 and rs2075938 of the NCF4 gene are associated with the risk of chronic heart failure in patients with type 2 diabetes mellitus (n=1310). In particular, haplotypes ATGTCTAT (OR=1.74, 95%CI=1.23-2.47; p=0.0017) and ATATTCAC (OR=2.83, 95%CI=1.33-6.03; p=0.0072) of NCF4 increase the risk of chronic heart failure in type 2 diabetes mellitus patients. The results show that NADPH oxidase subunit NCF4 is involved in the molecular mechanisms of myocardial damage in type 2 diabetes mellitus.
Asunto(s)
Diabetes Mellitus Tipo 2 , Insuficiencia Cardíaca , Humanos , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/genética , Polimorfismo de Nucleótido Simple/genética , NADPH Oxidasas/genética , Haplotipos/genética , Insuficiencia Cardíaca/genética , Predisposición Genética a la Enfermedad/genéticaRESUMEN
L-arginine (200 mg/kg), vitamin B(6) (2 mg/kg), and folic acid (0.2 mg/kg) exert a protective effect on endothelial function in L-NAME-induced NO deficiency in male and pregnant female Wistar rats. Combined administration of these agents effectively prevented the development of endothelial dysfunction and L-NAME-induced preeclampsia.
Asunto(s)
Arginina/farmacología , Endotelio/fisiopatología , Ácido Fólico/farmacología , Óxido Nítrico/deficiencia , Placenta/irrigación sanguínea , Vitamina B 6/farmacología , Animales , Arginina/uso terapéutico , Quimioterapia Combinada , Endotelio/efectos de los fármacos , Endotelio/metabolismo , Femenino , Ácido Fólico/uso terapéutico , Masculino , Microcirculación/efectos de los fármacos , NG-Nitroarginina Metil Éster , Óxido Nítrico Sintasa de Tipo III/metabolismo , Placenta/efectos de los fármacos , Placenta/metabolismo , Preeclampsia/inducido químicamente , Preeclampsia/tratamiento farmacológico , Preeclampsia/metabolismo , Embarazo , Ratas , Ratas Wistar , Vitamina B 6/uso terapéuticoRESUMEN
Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs.
Asunto(s)
Endotelio Vascular/patología , Hiperhomocisteinemia/fisiopatología , Enfermedades Vasculares/fisiopatología , Animales , Endotelio Vascular/efectos de los fármacos , Hiperhomocisteinemia/complicaciones , Hiperhomocisteinemia/tratamiento farmacológico , Metionina/uso terapéutico , Ratas , Enfermedades Vasculares/tratamiento farmacológico , Enfermedades Vasculares/etiologíaRESUMEN
The influence of immobilized proteases such as catalytin (a complex preparation containing the protease terrilytin and the antiseptic catapol) and streptodecase (an activator of fibrinolysis proteases) on the humoral immune response induced by the thymus-dependent antigen (SRBC) under conditions of burns and Staphylococcus infected burns was studied. The immobilized proteases catalytin and streptodecase had an immunostimulating effect under conditions of extended burns. Catalytin had an immunocorrigating effect under conditions of the infected burns. It was suggested that the complex enzyme-containing preparation catalytin and the immobilized activator of fibrinolysis proteases streptodecase were promising immunopharmacological agents in combined treatment of pathological processes accompanied by the development of immune deficiency as a secondary condition.