RESUMEN
OBJECTIVE: The association between diabetes mellitus and tuberculosis is a health-threatening double trouble. Vulnerable populations such as refugees and conflict-displaced populations may be at higher risk of both diseases. Here, we examined the prevalence of latent tuberculosis infection (LTBI) and its associated risk factors in a population of Syrian refugees with diabetes in North Lebanon. STUDY DESIGN: This is a cross-sectional study. METHODS: A total of 87 Syrian refugees with diabetes were enrolled. Demographic and clinical data were collected using a structured questionnaire, and a blood sample was obtained from each patient. LTBI was examined using the last generation QuantiFERON-TB Gold Plus assay. RESULTS: The mean age of the study population was 54.1 ± 10.5 years, and the majority were women (79.3%). LTBI was found in 1 in 5 (17/87; 19.5%) enrolled patients, with the majority being originated from Aleppo (47.05%). Infection was significantly associated only with age (P = 0.009), and its risk was 4-fold higher in patients aged ≥60 years (odds ratio: 4.1, confidence interval: 1.4-12.5, P = 0.018). CONCLUSION: This study highlights the need to implement effective tuberculosis control strategies among refugees with diabetes, with particular attention to those at older age.
Asunto(s)
Diabetes Mellitus/epidemiología , Tuberculosis Latente/epidemiología , Refugiados/estadística & datos numéricos , Adulto , Estudios Transversales , Femenino , Humanos , Líbano/epidemiología , Masculino , Persona de Mediana Edad , Oportunidad Relativa , Prevalencia , Factores de Riesgo , Encuestas y Cuestionarios , Siria/epidemiologíaAsunto(s)
Antifúngicos/uso terapéutico , Candida/clasificación , Candidiasis/epidemiología , Candidiasis/microbiología , Farmacorresistencia Fúngica , Antifúngicos/farmacología , Candida/efectos de los fármacos , Candida/aislamiento & purificación , Candidiasis/tratamiento farmacológico , Estudios Transversales , Fluconazol/farmacología , Fluconazol/uso terapéutico , Hospitales/estadística & datos numéricos , Humanos , Líbano/epidemiología , Pruebas de Sensibilidad Microbiana , Proyectos Piloto , PrevalenciaRESUMEN
In recent decades, the epidemiology of invasive candidiasis (IC) has progressively changed worldwide. This notably includes emergence of several Candida species. Although some surveillance programs provided global trends in IC epidemiology, data from countries from the Middle East and North Africa (MENA) remain scarce. In this manuscript, we reviewed the existing available data on the epidemiology of Candida species associated with IC, particularly candidemia, in MENA region regarding species distribution. As witnessed worldwide, an evident shift of Candidaalbicans towards non-albicansCandida (NAC) has been observed in the MENA region. The worrying emergence of multi-drug resistant Candida species in MENA calls for a better understanding of their epidemiology. This represents an essential prerequisite for the implementation of effective infection control strategies and surveillance systems to prevent IC among high-risk patients.
Asunto(s)
Candidemia/epidemiología , Candidiasis Invasiva/epidemiología , Farmacorresistencia Fúngica Múltiple , África del Norte/epidemiología , Antifúngicos/uso terapéutico , Candida/clasificación , Candida/fisiología , Candidemia/tratamiento farmacológico , Candidemia/prevención & control , Candidiasis Invasiva/tratamiento farmacológico , Candidiasis Invasiva/prevención & control , Humanos , Medio Oriente/epidemiologíaRESUMEN
1. The real burden of Campylobacter spp. in Lebanon is still unknown. The aims of this study were to unravel the epidemiology of Campylobacter spp. in broilers at slaughterhouses in Tripoli, North of Lebanon and to characterise their antibiotic resistance profiles.2. From May to November 2015, sampling was performed through five repeated surveys from 15 slaughterhouses that sold chicken directly to Lebanese customers. Isolates were subjected to pulsed field gel electrophoresis (PFGE) and flaA-restriction fragment length polymorphism (flaA-RFLP).3. All investigated slaughterhouses were found to be positive for Campylobacter spp. Campylobacter coli was the predominant species (38 isolates) followed by C. jejuni (eight isolates). A noticeable level of resistance was detected among isolates against ciprofloxacin (97% of C. coli and 87.5% of C. jejuni), amoxicillin (89% of C. coli and 75% of C. jejuni), gentamicin (79% of C. coli and 50% of C. jejuni), and co-amoxiclav (24% of C. coli and 25% of C. jejuni). Erythromycin and ertapenem resistance were observed only in C. coli with the following percentages 74% and 13% respectively, but not in C. jejuni. PFGE and flaA-RFLP using DdeI as restriction enzyme divided the strains into 27 and 25 types respectively.4. The high observed genetic diversity of Campylobacter spp. revealed the complexity of the spread of this genus in broilers. This study highlighted the pressing need to monitor antibiotic resistance and to ensure food safety from 'farm to fork' in Lebanon.
Asunto(s)
Infecciones por Campylobacter/veterinaria , Campylobacter/efectos de los fármacos , Pollos/microbiología , Enfermedades de las Aves de Corral/epidemiología , Mataderos , Animales , Antibacterianos/farmacología , Campylobacter/clasificación , Campylobacter/genética , Infecciones por Campylobacter/epidemiología , Infecciones por Campylobacter/microbiología , Ciego/microbiología , Farmacorresistencia Bacteriana , Electroforesis en Gel de Campo Pulsado/veterinaria , Flagelina/genética , Enfermedades Transmitidas por los Alimentos/epidemiología , Enfermedades Transmitidas por los Alimentos/microbiología , Variación Genética , Humanos , Líbano/epidemiología , Reacción en Cadena de la Polimerasa/veterinaria , Polimorfismo de Longitud del Fragmento de Restricción , Enfermedades de las Aves de Corral/microbiología , Prevalencia , Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción/veterinariaRESUMEN
Emergence of carbapenem-resistant Acinetobacter spp. has been increasingly reported worldwide. We report here the first detection of an Acinetobacter calcoaceticus isolate from vegetables in Lebanon carrying the bla Oxa-72 gene. These findings show that the Lebanese environment may constitute a potential reservoir for this antibiotic resistance gene.