RESUMEN
Twelve neurologically normal infants (age 2.9+/-0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity.
Asunto(s)
Antiulcerosos/uso terapéutico , Esofagitis Péptica/tratamiento farmacológico , Omeprazol/uso terapéutico , Cimetidina/uso terapéutico , Antagonistas de los Receptores H2 de la Histamina/uso terapéutico , Humanos , Lactante , Insuficiencia del Tratamiento , Resultado del TratamientoAsunto(s)
Anticonvulsivantes/efectos adversos , Densidad Ósea/efectos de los fármacos , Osteoporosis/inducido químicamente , Ácido Valproico/efectos adversos , Adolescente , Anticonvulsivantes/uso terapéutico , Epilepsia Tónico-Clónica/tratamiento farmacológico , Humanos , Masculino , Fracturas de la Columna Vertebral/etiología , Vértebras Torácicas/lesiones , Ácido Valproico/uso terapéuticoRESUMEN
Significant differences (p < 0.0001) were demonstrated in lymphocyte subpopulations both in cord blood and in venous blood samples obtained at day 5 from the same healthy infants. Numbers of T lymphocytes increased, especially CD4+/CD45RA+ cells, whereas numbers of B lymphocytes and natural killer cells decreased without changes in CD8+ and other cytotoxic cells.