RESUMEN
The >30 mutated residues in the Omicron spike protein have led to its rapid classification as a new SARS-CoV-2 variant of concern. As a result, Omicron may escape from the immune system, decreasing the protection provided by COVID-19 vaccines. Preliminary data shows a weaker neutralizing antibody response to Omicron compared to the ancestral SARS-CoV-2 virus, which can be increased after a booster vaccine. Here, we report that CD8+ T cells can recognize Omicron variant epitopes presented by HLA-A*02:01 in both COVID-19 recovered and vaccinated individuals, even 6 months after infection or vaccination. Additionally, the T cell response was stronger for Omicron variant epitopes after the vaccine booster. Altogether, T cells can recognize Omicron variants, especially in vaccinated individuals after the vaccine booster. One-Sentence SummaryCD8+ T cells response against Omicron variant epitopes is stronger after the vaccine booster.
RESUMEN
Organizational citizenship behaviors (OCBs) are commonly studied in the organizational and occupational health literature, yet, current OCB measures inherently assume individuals are performing these behaviors while physically at work. However, recent technological advances have afforded employees greater flexibility to engage in work-related behaviors at home, begging the question of whether OCBs are also being performed from home and their distinction from traditional OCBs. We provide evidence that OCBs performed while physically at work (OCB-W; i.e., traditional OCBs) are conceptually and empirically distinct from OCBs performed while physically at home (OCB-H). In Study 1 (N = 292), we examine construct validity evidence for OCB-H with regard to its distinction from OCB-W and its unique nomological network. In Study 2, we further examine the distinction between OCB-H and OCB-W at the between- and within-person level using an experience sampling approach in a sample of 162 workers. Using results from multilevel confirmatory factor analysis, we show that between-person variance in OCB-H is considerably higher than for OCB-W, and that although OCB-H and OCB-W are strongly correlated at the between-person level, they are independent of one another at the within-person level. We also examine these two forms of OCB as parallel mediators of the relation between work engagement and work interfering with family. Results suggest OCB-H and OCB-W are indeed distinct in the strength of their relationships to work engagement and work interfering with family at between- and within-person levels. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Asunto(s)
Participación Social , Compromiso Laboral , Equilibrio entre Vida Personal y Laboral , Adulto , Conflicto Familiar , Femenino , Humanos , Masculino , Persona de Mediana Edad , Cultura Organizacional , Psicometría , Reproducibilidad de los Resultados , Conducta Social , Encuestas y Cuestionarios/normas , Teletrabajo , Estados UnidosRESUMEN
Scholarly interest in workaholism has increased dramatically in recent years. This research has underscored the detrimental effects of workaholism for employees, their families, and the organizations that employ them. Despite drastic improvements in the quality of studies examining workaholism over the past several decades, researchers continue to almost exclusively rely on older measures of workaholism or new measures derived from these original measures. In the present study, we outline why a new measure is needed and propose a multidimensional conceptualization of workaholism that encompasses motivational, cognitive, emotional, and behavioral dimensions. We then develop and validate a new multidimensional measure of workaholism: the Multidimensional Workaholism Scale (MWS). Evidence from 5 samples representing individuals working in a wide variety of occupations and industries throughout the United States (total N = 1,252) provides support that (a) our proposed 4-factor structure replicates and fits better than alternative models; (b) the measure demonstrates high reliability and content validity; (c) the measure demonstrates evidence for convergent and discriminant validity with constructs in workaholism's nomological network; (d) the measure demonstrates incremental validity in the prediction of important outcomes over and above prior measures of workaholism; and (e) the different dimensions demonstrate incremental validity in the prediction of specific outcomes over and above other dimensions of the MWS. Overall, results from the present study suggest that the MWS is a reliable and valid measure that can advance a more nuanced approach to research and practice relating to workaholism. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Asunto(s)
Conducta Adictiva/psicología , Escalas de Valoración Psiquiátrica , Compromiso Laboral , Trabajo/psicología , Adulto , Formación de Concepto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Psicometría , Reproducibilidad de los Resultados , Adulto JovenRESUMEN
STUDY QUESTION: Can host fertility be rescued by grafting of a fragment of a healthy ovary soon after chemotherapy? SUMMARY ANSWER: We found that grafting a green fluorescent protein (GFP)-positive fragment from a healthy isogenic ovary to the left ovary of a chemo-treated host rescued function and fertility of the grafted host ovary, and resulted in the production of host-derived offspring as late as the sixth litter after chemotherapy (CTx) treatment, whereas none of the ungrafted controls produced a second litter. WHAT IS KNOWN ALREADY: In women and girls undergoing chemotherapy, infertility and premature ovarian failure are frequent outcomes. There are accumulating reports of improved endocrine function after autotransplantation of an ovarian fragment, raising the possibility that the transplant is beneficial to the endogenous ovary. STUDY DESIGN, SIZE, DURATION: We first established a CTx treatment regimen that resulted in the permanent loss of fertility in 100% of female mice of the FVB inbred strain. We grafted an isogenic ovary fragment from a healthy female homozygous for a GFP transgene to the left ovary of 100 CTx-treated hosts, and compared fertility to 39 ungrafted controls in 6 months of continuous matings, using GFP to distinguish offspring derived from the graft, and those derived from the host. PARTICIPANTS/MATERIALS, SETTING, METHODS: Immunofluoresece and western blot analysis of 39 treated ovaries during and 15 days after CTx treatment revealed elevated apoptosis, rapid loss of granulosa cells and an increased recruitment of growing follicles. Using immunofluorescence and confocal imaging, we tracked the outcome of the grafted tissue over 4 months and its effect on the adjacent and contralateral ovary of the host. MAIN RESULTS AND THE ROLE OF CHANCE: Fifty-three percent of grafted females produced a second litter whereas none of the ungrafted females produced a second litter. The likelihood that this could occur by chance is very low (P < 0.0001). LIMITATIONS, REASONS FOR CAUTION: These results are shown only in mice, and whether or how they might apply to chemotherapy patients subjected to different CTx regimens is not yet clear. WIDER IMPLICATIONS OF THE FINDINGS: Our experiments prove that rescue of a chemo-treated ovary is possible, and establish a system to investigate the mechanism of rescue and to identify the factors responsible with the long-term goal of developing therapies for preservation of ovarian endocrine function and fertility in women undergoing chemotherapy. LARGE SCALE DATA: No large datasets were produced. STUDY FUNDING/COMPETING INTERESTS: Duke University Medical Center Chancellor's Discovery Grant to BC; ESJ was supported by an NRSA 5F31CA165545; SK was supported by NIH RO1 GM08033; RWT was supported by the Duke University School of Medicine Ovarian Cancer Research Fellowship; XBM was supported by CONICYT. The authors have no conflicts of interest to declare.