RESUMEN
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Asunto(s)
Humanos , Femenino , Anciano de 80 o más Años , Procedimientos Quirúrgicos Torácicos/clasificación , Procedimientos Quirúrgicos Torácicos/métodos , Procedimientos Quirúrgicos Torácicos/tendencias , Prótesis e Implantes/clasificación , Pared Torácica/lesiones , Prótesis e Implantes/tendencias , Prótesis e ImplantesAsunto(s)
Neoplasias Óseas/cirugía , Condrosarcoma/cirugía , Procedimientos de Cirugía Plástica/instrumentación , Pared Torácica/cirugía , Anciano de 80 o más Años , Femenino , Humanos , Politetrafluoroetileno/uso terapéutico , Procedimientos de Cirugía Plástica/métodos , Costillas/cirugía , Esternón/cirugíaRESUMEN
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No disponible
Asunto(s)
Humanos , Femenino , Adolescente , Carcinoma Papilar/cirugía , Escisión del Ganglio Linfático/métodos , Recurrencia Local de Neoplasia/cirugía , Neoplasias de la Tiroides/cirugía , Mediastino , CuelloRESUMEN
El dermatofibroma es una lesión cutánea común en la práctica dermatológica. La manifestación típica es una pápula de crecimiento lento, firme y solitaria. Desde el punto de vista histopatológico, se define en ocasiones como una reacción del tejido conectivo dérmico y en otras como una proliferación neoplásica benigna. En 1990 se publicó por primera vez la existencia de metástasis pulmonares de este tumor. Desde entonces se han recogido en todo el mundo 12 casos de similares características. Presentamos el caso de una mujer joven con un dermatofibroma recidivante en el hombro y metástasis pulmonares bilaterales. Analizamos qué características histológicas del tumor podrían hacer sospechar un comportamiento posterior inusualmente agresivo(AU)
Dermatofibromas are very common skin tumors. Their typical presentation is as a slow-growing, firm, solitary papule. They have been described histopathologically as a reaction of the connective tissue of the skin or as a benign neoplasm. Cases of these tumors metastasizing to the lung were first reported in 1990. Since then 12 cases with similar characteristics have been reported worldwide. We present the case of a young woman with a recurrent dermatofibroma on the shoulder that metastasized to both lungs. We discuss the histologic characteristics of this tumor that could raise suspicion of unusually aggressive behavior(AU)
Asunto(s)
Humanos , Femenino , Adulto , Histiocitoma Fibroso Benigno , Histiocitoma Fibroso Benigno/complicaciones , Histiocitoma Fibroso Benigno/diagnóstico , Histiocitoma Fibroso Benigno/epidemiología , Histiocitoma Fibroso Benigno/etiología , Histiocitoma Fibroso Benigno/cirugía , Histiocitoma Fibroso Benigno/terapia , Histiocitoma Fibroso Benigno , Metástasis de la Neoplasia , Metástasis de la Neoplasia/terapia , Histología , Informes de CasosRESUMEN
Dermatofibromas are very common skin tumors. Their typical presentation is as a slow-growing, firm, solitary papule. They have been described histopathologically as a reaction of the connective tissue of the skin or as a benign neoplasm. Cases of these tumors metastasizing to the lung were first reported in 1990. Since then 12 cases with similar characteristics have been reported worldwide. We present the case of a young woman with a recurrent dermatofibroma on the shoulder that metastasized to both lungs. We discuss the histologic characteristics of this tumor that could raise suspicion of unusually aggressive behavior.
Asunto(s)
Histiocitoma Fibroso Benigno/secundario , Neoplasias Pulmonares/secundario , Neoplasias Cutáneas/patología , Adulto , Dermis/patología , Femenino , Histiocitoma Fibroso Benigno/diagnóstico por imagen , Histiocitoma Fibroso Benigno/cirugía , Humanos , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/cirugía , Recurrencia Local de Neoplasia/cirugía , Neumonectomía , Tomografía de Emisión de Positrones , Hombro , Neoplasias Cutáneas/cirugía , ToracotomíaRESUMEN
BACKGROUND: The prognostic significance of the presence of a neuroendocrine marker (synaptophysin, SY) was analyzed in stage I of squamous carcinoma and adenocarcinoma of the lung. METHODS: A multicentric retrospective study was conducted with immunohistochemical staining in a single center of 318 patients resected for squamous carcinoma or adenocarcinoma in pathologic stage I. RESULTS: In all, 162 cases of squamous carcinoma and 156 cases of adenocarcinoma were identified, which included 105 patients in stage IA (50 patients with squamous carcinoma and 55 patients with adenocarcinoma) and 213 in stage IB (112 with squamous carcinoma and 101 with adenocarcinoma). Eighty-six tumors showed a presence of SY+ (27%). Univariate analysis showed lower survival rates at 5 years for those patients older than 70 years of age compared with those patients younger than 70 years of age (60.35% vs 70.57%; P = .007) and for those patients with SY+ compared with those with SY- (52.48% vs 72.68%; P = .0017). Patients with SY+ tumors showed a higher rate of recurrence than patients with SY- tumors (50% vs 33.6%; P = .008). Multivariate analysis showed that those patients greater that 70 years of age (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.14-2.65) and the presence of SY (HR, 2.15; 95% CI, 1.40-3.30) were significant independent prognostic factors associated with a poor outcome. CONCLUSIONS: Stage I of squamous carcinoma and adenocarcinoma of the lung with SY+ has a poor prognosis, with a higher frequency of recurrence and lower survival rates.