1.
Angew Chem Int Ed Engl
; 61(18): e202117233, 2022 04 25.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35112447
RESUMEN
We report the first example of selective PdII -catalyzed tertiary C-H activation of cyclobutylmethyl ketones using a transient directing group. An electron-deficient 2-pyridone ligand was identified as the optimal external ligand to enable tertiary C-H activation. A variety of cyclobutylmethyl ketones bearing quaternary carbon centers was readily accessed without preinstalling internal directing groups in up to 81 % yield and >95 : 5 regioisomeric ratios of tertiary C-H arylation to ß-methylene (ß-methyl) or γ-C-H arylation.