RESUMEN
Allopurinol-induced drug reactions with eosinophilia and systemic symptoms (DRESS) is a severe illness related to hypersensitivity syndrome characterized by fever, skin rash, lymph node enlargement, hematological abnormalities, especially eosinophilia and atypical lymphocytosis, and single or multiple organ involvement. The syndrome is difficult to diagnose in view of its clinical heterogeneity and long latency period within 8 weeks after start treatment. We report a case of DRESS syndrome in a 64-year-old man, induced by allopurinol treatment for asymptomatic hyperuricemia, started 8 weeks earlier but stopped only 3 days after because of the onset of rash. The diagnosis was retained due to combining of interstitial nephritis with the clinical findings of fever, skin rash, cervical lymphadenopathy, eosinophilia, and reactivation of human herpesviruses specifically HHV-6. The glucocorticoids were started to relieve hypersensitivity. Five days later, the patient became afebrile, and the rash improved significantly. However, interstitial nephritis with renal function impairment progressed to severe azotemia, and even anuria requiring hemodialysis. Allopurinol-induced DRESS syndrome is associated with significant mortality, and care must, therefore, be exercised when given this drug.
RESUMEN
INTRODUCTION: Psammomatoid cemento-ossifying fibroma (PCOF) is a rare benign fibro-osseous lesion. It affects the maxilla, the nasal cavity, paranasal sinuses, and the ethmoid. It is slow-growing, progressive, and benign but it can be locally extended and mimic a malignant tumor. OBSERVATION: We report the unusual case of a 36-year-old woman with a nasal and ethmoid PCOF with orbital and endocranial extension. The tumor was revealed by exophthalmia and nasal obstruction. The diagnosis was proven histologicaly on biopsies. The treatment was transfacial surgery. There was no recurrence 1 year later. DISCUSSION: Intraorbital and endocranial extension of PCOF are rare aggressive behaviours. Histologically, the differential diagnosis is difficult between fibrous dysplasia or psammomatoid meningioma. Complete surgical excision is necessary to prevent recurrence.
Asunto(s)
Senos Etmoidales/patología , Fibroma Osificante/diagnóstico , Neoplasias Nasales/diagnóstico , Neoplasias Orbitales/diagnóstico , Neoplasias de los Senos Paranasales/diagnóstico , Adulto , Biopsia , Diagnóstico Diferencial , Exoftalmia/diagnóstico , Femenino , Fibroma Osificante/patología , Humanos , Obstrucción Nasal/diagnóstico , Invasividad Neoplásica , Neoplasias Nasales/patología , Neoplasias Orbitales/patología , Neoplasias de los Senos Paranasales/patología , Neoplasias Craneales/diagnósticoRESUMEN
Tuberculous of the oral cavity is rare, the attack tonsil remains exceptional. We report case a 25-year-old young male, who consults for an ulceration of the left unilateral tonsil, with a homolateral adenopathy jugulo-carotidien. The examination anatomopathologic of the tonsil biopsy revealed a tuberculous of the tonsil. The patient profited from an antituberculous treatment, the evolution was good.
Asunto(s)
Tonsilitis/microbiología , Tuberculosis/diagnóstico , Adulto , Antituberculosos/uso terapéutico , Diagnóstico Diferencial , Humanos , Masculino , Neoplasias Tonsilares/diagnóstico , Tonsilitis/diagnóstico , Tonsilitis/tratamiento farmacológico , Tuberculosis/tratamiento farmacológicoRESUMEN
The laryngeal tuberculous is the most frequent granulomatous disease of the larynx. It is generally associated with a pulmonary cave, and represents a prognosis element extremely serious and can be complicated extreme dysphagia and pains. Among all the extrapulmonary localisations. The isolated laryngée localisation is rare. It is secondary the dissemination coming hematogen, air or lymphatic way. All the structures of the larynx can be reached. The beginning is progressive and insidious and appears by the dysphony, cough, the odynophagy and dyspnea. We report the case of laryngeal tuberculosis in a 21 year old young man. The authors point out the characteristics of this localization and insist on the biopsy in front of any chronic laryngitis no aetiology. The treatment is medical.
Asunto(s)
Tuberculosis Laríngea/complicaciones , Tuberculosis Laríngea/diagnóstico , Adulto , Humanos , Masculino , Índice de Severidad de la Enfermedad , Tuberculosis Laríngea/patología , Trastornos de la Voz/diagnóstico , Trastornos de la Voz/etiologíaRESUMEN
INTRODUCTION: Ganglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms. CASE REPORT: We report the case of a 22 year-old man who presented a ganglioneuroma localized in the zygoma. DISCUSSION: Ganglioneuroma generally develop in the abdomen or thorax soft tissue. The occurrence of ganglioneuroma in the bone is exceptional. To date less than ten cases have been reported, six of which involved the mandible. We discuss the possible causes of tumor development at this site.