RESUMEN
The impact of standardized antimycobacterial treatment versus a complex combination of chemo- and ozonotherapy on the T and B links and specific antituberculous immunity was studied in patients with destructive pulmonary tuberculosis. A course of ozonotherapy was performed in the early intensive phase of antimycobacterial therapy via endovascular injection of ozonized 0.9% NaCl solution. Ozonotherapy used in the early intensive phase of the standardized treatment in patients with destructive pulmonary tuberculosis results in normalization of the count of tuberculin-sensitized T cells and the number of PPD-L proliferating lymphocytes, promotes decreased tuberculin sensitivity, accelerates normalization of humoral immunity (IgM, IgE), and activates the proliferative capacity of T cells in the early periods.