Asunto(s)

RESUMEN

Introducción: En pacientes con deterioro cognitivo leve y demencia, son frecuentes los síntomas neuropsiquiátricos, que pueden aparecer o exacerbarse ante los cambios en la rutina y el entorno habitual del paciente. La situación de confinamiento durante la pandemia de la COVID-19 ha supuesto un cambio en la vida cotidiana de la población general, con especial impacto en los grupos más vulnerables, como los pacientes con afectación cognitiva. Objetivo: Conocer la repercusión de las medidas de confinamiento y cuarentena impuestas por la pandemia de la COVID-19 en la sintomatología neuropsiquiátrica en personas con deterioro cognitivo leve (DCL) y demencia. Materiales y métodos: Revisión sistemática exploratoria, siguiendo las directrices PRISMA, de artículos en las bases datos PubMed y PsycINFO publicados entre enero de 2020 y abril de 2021, que relacionaron el confinamiento por la COVID-19 con la presentación o el empeoramiento de síntomas neuropsiquiátricos en pacientes con DCL o con demencia. Resultados: Se observó un empeoramiento de los síntomas neuropsiquiátricos en los pacientes con demencia y DCL, especialmente agitación/agresión, ansiedad, depresión y apatía. Los síntomas neuropsiquiátricos fueron más comunes en los pacientes con demencia que en los que presentaban DCL, aunque su tipología varió en función de la gravedad de la demencia. Conclusiones: Durante el confinamiento se ha objetivado un detrimento en la esfera psicoconductual en personas con DCL o demencia. Consecuentemente, surge la reflexión sobre la necesidad de fomentar el contacto social en las personas con DCL y demencia, evitando las situaciones de aislamiento y baja estimulación.(AU)

Introduction: Neuropsychiatric symptoms are common in patients with mild cognitive impairment and dementia. This symptomatology can appear or be exacerbated with changes in routine and in the patient’s usual environment. The lockdown situation during the COVID-19 pandemic has meant a drastic and unexpected change in the daily life of the general population, with a particular impact on the most physically and mentally vulnerable groups, including patients with cognitive impairment. Aim: To know the impact of lockdown measures imposed due to the COVID-19 pandemic on neuropsychiatric symptomatology in people with mild cognitive impairment and dementia. Materials and methods. Exploratory systematic review, in accordance with the PRISMA guidelines, of Pubmed and Psycinfo databases papers published from January 2020 to April 2021 which related confinement due to COVID-19 with the presentation or worsening of neuropsychiatric symptoms in patients with mild cognitive impairment mild or dementia. Results: Worsening of neuropsychiatric symptoms was observed in patients with dementia and mild cognitive impairment, especially agitation/aggression, anxiety, depression and apathy. Neuropsychiatric symptoms were more common in patients with dementia than in those with mild cognitive impairment, although their typology varied depending on the severity of dementia. Conclusions: During lockdown a worsening in the psychobehavioral area has been observed in people with mild cognitive impairment or dementia. Therefore, considerations arise on the need of promoting social contact in people with mild cognitive impairment and dementia, avoiding situations of isolation and low stimulation.(AU)

Asunto(s)

RESUMEN

INTRODUCTION: Neuropsychiatric symptoms are common in patients with mild cognitive impairment and dementia. This symptomatology can appear or be exacerbated with changes in routine and in the patient's usual environment. The lockdown situation during the COVID-19 pandemic has meant a drastic and unexpected change in the daily life of the general population, with a particular impact on the most physically and mentally vulnerable groups, including patients with cognitive impairment. AIM: To know the impact of lockdown measures imposed due to the COVID-19 pandemic on neuropsychiatric symptomatology in people with mild cognitive impairment and dementia. MATERIALS AND METHODS: Exploratory systematic review, in accordance with the PRISMA guidelines, of Pubmed and Psycinfo databases papers published from January 2020 to April 2021 which related confinement due to COVID-19 with the presentation or worsening of neuropsychiatric symptoms in patients with mild cognitive impairment mild or dementia. RESULTS: Worsening of neuropsychiatric symptoms was observed in patients with dementia and mild cognitive impairment, especially agitation/aggression, anxiety, depression and apathy. Neuropsychiatric symptoms were more common in patients with dementia than in those with mild cognitive impairment, although their typology varied depending on the severity of dementia. CONCLUSIONS: During lockdown a worsening in the psychobehavioral area has been observed in people with mild cognitive impairment or dementia. Therefore, considerations arise on the need of promoting social contact in people with mild cognitive impairment and dementia, avoiding situations of isolation and low stimulation.

TITLE: Síntomas neuropsiquiátricos en personas con demencia relacionados con el confinamiento por la pandemia de la COVID-19. Revisión sistemática exploratoria.Introducción. En pacientes con deterioro cognitivo leve y demencia, son frecuentes los síntomas neuropsiquiátricos, que pueden aparecer o exacerbarse ante los cambios en la rutina y el entorno habitual del paciente. La situación de confinamiento durante la pandemia de la COVID-19 ha supuesto un cambio en la vida cotidiana de la población general, con especial impacto en los grupos más vulnerables, como los pacientes con afectación cognitiva. Objetivo. Conocer la repercusión de las medidas de confinamiento y cuarentena impuestas por la pandemia de la COVID-19 en la sintomatología neuropsiquiátrica en personas con deterioro cognitivo leve (DCL) y demencia. Materiales y métodos. Revisión sistemática exploratoria, siguiendo las directrices PRISMA, de artículos en las bases datos PubMed y PsycINFO publicados entre enero de 2020 y abril de 2021, que relacionaron el confinamiento por la COVID-19 con la presentación o el empeoramiento de síntomas neuropsiquiátricos en pacientes con DCL o con demencia. Resultados. Se observó un empeoramiento de los síntomas neuropsiquiátricos en los pacientes con demencia y DCL, especialmente agitación/agresión, ansiedad, depresión y apatía. Los síntomas neuropsiquiátricos fueron más comunes en los pacientes con demencia que en los que presentaban DCL, aunque su tipología varió en función de la gravedad de la demencia. Conclusiones. Durante el confinamiento se ha objetivado un detrimento en la esfera psicoconductual en personas con DCL o demencia. Consecuentemente, surge la reflexión sobre la necesidad de fomentar el contacto social en las personas con DCL y demencia, evitando las situaciones de aislamiento y baja estimulación.

Asunto(s)

RESUMEN

Microorganisms play a key role in the carbon (C) cycle through soil organic matter (SOM). The rate of SOM mineralization, the influence of abiotic factors on this rate and the potential behaviour of SOM are of particular interest in the northern Antarctic Peninsula and offshore islands. This is one of the most rapidly warming regions on Earth with numerous ice-free areas, some with abundant wildlife and with the greatest known soil organic carbon (SOC) storage in Antarctica. The latter implies extended Antarctic summer conditions promote increased terrestrial plant growth and soil microbial activity (SMA). SMA, determined by respirometry, is a measure of ecosystem function, and depends on microclimatic conditions and soil environmental properties. SMA and the effect of abiotic variables have been analysed in locations with different soil types, on Cierva Point (Antarctic Peninsula), Deception Island and Fildes Peninsula (King George Island). Soil microbial biomass carbon (SMBC) ranged from 5.66 to 196.6 mg SMBC kg-1and basal respiration (BR) from 2.86 to 160.67 mg CO2 kg-1 d-1. SMBC and BR values were higher in Cierva Point, followed by Fildes Peninsula and Deception Island, showing the same trend of SOM abundance. Except for Cierva Point, low nitrogen, phosphorus and C concentrations were observed. SMBC/total organic carbon (TOC) levels indicated that SOC was recalcitrant and SOM content was closely related to the extent of vegetation cover observed in situ. High metabolic quotient values obtained at Cierva Point and Deception Island (median values 7.27 and 6.53 mg C-CO2 g SMBC-1 h-1) and low SMBC/TOC in Cierva Point suggest a poor efficiency of the microbial populations in the consumption of the SOC. High SMBC/TOC values obtained in Deception Island indicates that SMBC may influence SOM stabilization. Mineralization rates were very low (negligible values to 1.44%) and sites with the lowest values had the highest SOM.

Asunto(s)

RESUMEN

OBJECTIVES: The aim of this study was to evaluate the risk factors for candidaemia in patients with liver cirrhosis. METHODS: This was a case-control-control (1:2:2) study performed in four Italian tertiary centres from 2006 to 2015. Cases were patients with liver cirrhosis developing candidaemia. For every case of candidaemia we enrolled two additional patients undergoing blood cultures for suspected infection yielding isolation of a bacterial pathogen (control A) and two additional patients undergoing blood cultures for suspected infection yielding negative results (control B). Patients were matched according to age, sex and model for end stage liver disease at hospital admission. RESULTS: During the study period 90 cases, 180 controls A and 180 controls B were included. At multivariate analysis assessed by means of multinomial conditional regression models, factors independently associated with candidaemia were previous (<30 days) acute-on-chronic liver failure (relative risk ratio (RRR) 2.22 (95% confidence interval (CI) 1.09-4.54), p = 0.046), previous(<30 days) gastrointestinal endoscopy (RRR 2.38 (95% CI 1.19-4.78) p = 0.014), previous(<30 days) antibiotic treatment for at least 7 days (RRR 2.74 (95% CI 1.00-7.48), p = 0.049), presence of central venous catheter (RRR 2.77 (95% CI 1.26-6.09, p = 0.011), total parenteral nutrition (RRR 3.90 (95% CI 1.62-9.40), p = 0.002) at infection onset and length of in-hospital stay >15 days (RRR 4.63 (95% CI 2.11-10.18), p <0.001] Conversely, rifaximin treatment was associated with lower rate of candidaemia (RRR 0.38 (95% CI 0.19-0.77), p = 0.007). Multivariable analysis for 30-day mortality showed that patients with isolation of Candida spp. from blood cultures had worse outcome when compared with controls even though the difference did not reach a statistical significance (hazard ratio 1.64 (95% 0.97-2.75) p = 0.06). CONCLUSIONS: We identified previous antibiotic use, gastrointestinal endoscopy or acute-on-chronic liver failure and presence of central venous catheter especially for parenteral nutrition as independent factors associated with candidaemia. Surprisingly, chronic rifaximin use was a protective factor.

Asunto(s)

RESUMEN

The primary study objective was to investigate three decades from 1985 to 2014 of changes in pregnancies among HIV-infected women. The secondary objective was to assess risk factors associated with preterm delivery and severe small-for-gestational-age (SGA) infants in HIV-infected women. A retrospective review of deliveries among pregnant HIV-infected women at the University of Genoa and IRCCS San Martino-IST in Genoa between 1985 and 2014 was performed. Univariate and multivariable analyses were used to study the variables associated with neonatal outcomes. Overall, 262 deliveries were included in the study. An increase in median age (26 years in 1985-1994 vs. 34 years in 2005-2014), in the proportion of foreigners (none in 1985-1994 vs. 27/70 (38·6%) in 2005-2014), and a decrease in intravenous drug use (75·2% (91/121) in 1985-1994 vs. 12·9% (9/70) in 2005-2014) among pregnant HIV-infected women was observed. Progressively, HIV infections were diagnosed sooner (prior to pregnancy in 80% (56/70) of women in the last decade). An increase in combined antiretroviral therapy (cART) prescription during pregnancy (50% (27/54) in 1995-2004 vs. 92·2% (59/64) in 2005-2014) and in HIV-RNA <50 copies/ml at delivery (19·2% (5/26) in 1995-2004 vs. 82·3% (53/64) in 2005-2014) was observed. The rate of elective caesarean section from 1985 to 1994 was 9·1%, which increased to 92·3% from 2004 to 2015. Twelve (10·1%) mother-to-child transmissions (MTCT) occurred in the first decade, and six (8·3%) cases occurred in the second decade, the last of which was in 2000. Preterm delivery (<37 weeks gestation) was 5% (6/121) from 1985 to 1994 and increased to 17·1% (12/70) from 2005 to 2014. In univariate and multivariable logistic regression analyses, advancing maternal age and previous pregnancies were associated with preterm delivery (odds ratio (OR) 2·7; 95% confidence intervals (CI) 1-7·8 and OR 2·6; 95% CI 1·1-6·7, respectively). In the logistic regression analysis, use of heroin or methadone was found to be the only risk factor for severe SGA (OR 3·1; 95% CI 1·4-6·8). In conclusion, significant changes in demographic, clinical and therapeutic characteristics of HIV-infected pregnant women have occurred over the last 30 years. Since 2000, MTCT has decreased to zero. An increased risk of preterm delivery was found to be associated with advancing maternal age and previous pregnancies but not with cART. The use of heroin or methadone has been confirmed as a risk factor associated with severe SGA.

Asunto(s)

RESUMEN

Introducción: El objetivo del artículo es realizar una revisión actualizada de las dificultades escolares de los niños y adolescentes con trastornos de X frágil. El síndrome X frágil (SXF) es la causa más frecuente de discapacidad intelectual hereditaria, así como una causa común de trastornos de aprendizaje y problemas conductuales. Se caracteriza por un fenotipo físico y un fenotipo conductual muy específicos. El SXF está causado por una mutación del gen FMRl (Fragüe X Mental Retardation), situado en la porción final del cromosoma X, locus Xq27.3. La mutación del gen produce un número anómalo de repeticiones de la tripleta CGG (Citosina-Guanina- Guanina). La mutación completa lleva consigo un estado de hipermetilación que inhibe la expresión del gen. El análisis del síndrome X frágil representa un buen modelo para determinar las relaciones entre genes y conducta. Desarrollo: El área de la lectura y la escritura en la población X frágil muestras demasiadas zonas oscuras. El número de trabajos de investigación básica y aplicada es escaso y mayoritariamente asume los patrones de comportamiento derivados de poblaciones próximas, como el síndrome Down, Autismo y síndrome Williams. Conclusión: Los principales problemas de los SXF con la lectura y la escritura tienen su origen en alteraciones de lenguaje y motoras y dificultades de integración sensorial. Nuestro trabajo pretende ampliar y sistematizar de manera orgánica algunos de los aspectos que consideramos fundamentales para mejorar la práctica educativa y la restauración de las deficiencias lectoras. En esta línea de actuación destacamos algunas estrategias metodológicas y propuestas programáticas que conviene explorar para conocer su valor pedagógico y su eficacia práctica.

Introduction: The article aims to provide an up-to-date review of the difficulties children and adolescents with fragile X disorders have in school. Fragile X syndrome (FXS) is the most frequent cause of hereditary intellectual disability, as well as being a common cause of learning disorders and behavioural problems. It is characterised by very specific physical and behavioural phenotypes. FXS is caused by a mutation in the FMR1 gene (Fragile X Mental Retardation) located at the bottom end of the X chromosome atXq27.3. This gene mutation produces an expansion in the number of CGG (Cytosine, Guanine, Guanine) triplet repetitions. The full mutation causes a state ofhypermethylation that inhibits gene expression. Analysis of fragile X syndrome represents a good model for determining the relationship between genes and behaviour. Development: There are many grey areas in the area of reading and writing in the fragile X population. Very few basic and applied research studies are available and they mostly assume behavioural patterns derived from comparable populations such as Down syndrome, Autism, and Williams syndrome. Conclusion: The main problems FXS children have with reading and writing stem from language and motor disorders and difficulties with sensorial integration. Our work aims to broaden and to systemize some of the aspects which we consider key to improving educational practice and to overcome reading deficiencies. In this direction, we highlight some programmatic proposals and methodological strategies which should be explored for their educational value and practical effectiveness.

Asunto(s)

RESUMEN

Se presenta el caso de un varón de 56 años con una tumoración de consistencia dura y localización submastoidea izquierda, con dolor y limitación leve de la movilidad cervical. Dado lo inhabitual de la localización, la concreción de la lesión y la corta evolución, se realizaron estudios de imagen (radiográficos y ecográficos), diagnosticándose una infrecuente tendinosis aguda de la inserción proximal del músculo esternocleidomastoideo (ECM) por manipulación quiropráctica realizada días antes

We present the case of a 56 year old man with left submastoid hard tumor, pain and little mobility limitation. Attending to the unusual location and the accute evolution, imaging studies (radiography and echography) were made, diagnosing a rare accute tendinosis of the sternocleiodomastoideus proximal insertation after chiropractic manipulation

Asunto(s)

RESUMEN

Introducción. El os odontoideum es un huesecillo redondo separado del axis por un defecto transversal, que deja al segmento apical sin soporte. Puede asociarse a determinadas displasias óseas como la polisacaridosis de Morquio y la displasia espondiloepifisaria. Su forma de presentación es variable, de tal manera que los síntomas de presentación pueden ser dolor de cuello, tortícolis o cefalea provocada por la irritación local de la articulación atloaxoidea. Los estudios radiológicos deben incluir siempre proyecciones laterales en flexión y extensión. Caso clínico. Se presenta el caso de un niño de diez años de edad, diagnosticado de una inestabilidad cervical C1-C2, tras realizarse unos estudios radiológicos rutinarios. Como antecedentes destacables presenta síndrome de Down e hipotiroidismo. Los estudios de tomografía axial computarizada (TAC) confirmaron el diagnóstico de inestabilidad atloaxoidea secundaria, asociada a os odontoideum. El paciente es intervenido quirúrgicamente realizándose una artrodesis posterior C1-C2

Introduction. The os odontoideum is a small round ossicle separated from the axis by a transverse defect that leaves the apical segment with no support. It may be associated with bone dysplasias such as Morquio's disease or mucopolysaccharidosis (MPS), and spondyloepiphyseal dysplasia. The mode of presentation of this condition is variable and symptoms on presentation may be neck pain, torticollis and headache caused by local irritation of the atloaxoid joint. X-ray studies must include lateral projections in flexion and extension. Case report. In this study we present a clinical case of a 10 year old boy diagnosed with cervical C1-C2 instability after a routine X-ray. Medical history included Down syndrome and hypothyroidism. Computed axial tomography (CAT) scans confirmed the diagnosis of secondary atloaxoid joint instability associated with os odontoideum. The patient underwent surgery and a subsequent C1-C2 arthrodesis was carried out

Asunto(s)

RESUMEN

No disponible

Asunto(s)

RESUMEN

PURPOSE: To evaluate the interchangeability of various commercially available iodine 125 ((125)I) sources and to assess the dosimetric effect of a change in source. MATERIALS AND METHODS: A modified peripherally loading prostate brachytherapy plan to deliver 145 Gy was devised by using a model (125)I source, which until recently was the only available (125)I source. A dose-volume histogram was generated. By using the available radial dose functions and anisotropy distributions for eight other currently commercially available sources, the same implant placement was planned and dose-volume histogram distributions tabulated. This exercise was performed for 15-, 45-, and 60-cm(3) glands. No implants were placed, and no physical radiation measurements were made. Dose calculations were theoretic: They were generated by using a widely available treatment planning system. RESULTS: There was little difference in dose distribution to the volume receiving 100% of the prescribed dose (<6%); only one source showed a difference greater than 2%. Large differences, up to -40% to +60%, were seen in the volume of tissue encompassed within internal high-dose regions receiving 150% or 200% of the prescribed dose. These findings held true, irrespective of gland size, within a clinically relevant range (15-60 cm(3)) and for a uniformly loaded radionuclide distribution. CONCLUSION: Reviewing only peripheral dose at or near the prescription dose of 145 Gy revealed little difference in doses for various source designs. Marked differences in high-dose regions were seen and may affect the dose received by internal sites. Effects of these changes on cure and/or complications remain speculative.

Asunto(s)

RESUMEN

PURPOSE: To assess the feasibility of real-time intraoperative treatment planning for permanent prostate brachytherapy analyzing the impact on operative time and adequacy of postimplant dosimetry. METHODS AND MATERIALS: Seventeen consecutive patients undergoing permanent brachytherapy for prostate cancer had real-time intraoperative computer-based and optimized treatment planning. The first 8 patients were implanted using a plan generated before the surgery and served to assure the team qualitatively that this could be performed without greatly increasing intraoperative time. They served as control group for expected achieved dosimetry results reviewing the D90, V100, V150 parameters from the dose-volume histograms. The next 9 patients were implanted according to the real-time plan. The times needed to carry out various steps of the procedure were recorded. The achieved dosimetry was then compared to the control group to assure that accuracy was unchanged. RESULTS: The median operative time for patients undergoing intraoperative dosimetry was 57 min. Of this, 21 min were devoted to anesthesia and nursing functions. Postoperative dosimetry showed a median achieved V100 (volume of prostate receiving 100% of prescribed dose) of 97% for the control group. For the real-time dosimetry group, the median V100 was similar at 94%. The V150 (volume receiving 150%) is 49% for both groups. The D90 (dose received by 90% of the target) was normalized for easy comparison and was consistently slightly greater than the prescription dose. CONCLUSION: Treatment planning for permanent brachytherapy of prostate cancer has historically been performed as a computer-generated and optimized plan run weeks in advance of an implant, or according to a set pattern using an intraoperative nomogram. These data show that planning can now be optimized intraoperatively using widely available software without compromising the operative time or implant quality.

Asunto(s)

RESUMEN

Objetivo: analizar los resultados de la apendicectomía laparoscópica y la apendicectomía abierta para comparar y evaluar ambos procedimientos realizados por el mismo equipo médico Sede: servicio de cirugía general del Hospital Regional 1§ de octubre y practica privada en la Ciudad de México. Diseño: estudio retrospectivo, observacional, con grupo control y seguimiento longiudinal. Material y métodos: se estudiaron los expedientes clínicos de 150 pacientes intervenidos quirúrgicamente de apendicectomía; todos procedían del servicio de urgencias con diagnóstico de apendicitis aguda y se dividieron en dos grupos: uno de 75 pacientes operados por vía tradicional y otro de 75 sujetos intervenidos por apendicectomía laparoscópica. Se excluyeron del estudio pacientes con operaciones previas en hemiabdomen inferior, con alteraciones que contraindicaban la anestesia general y mujeres embarazadas. Las variables analizadas fueron las siguientes: comienzo del tratamiento por vía oral, analgésico usados, estancia hospitalaria, complicaciones transoperatorias, reintervenciones quirúrgicas, índice de conversión, resultados histopatológicos y días de incapacidad posoperatoria. Resultados: éstos no mostraron diferencias estadísticas significativas en ambos grupos. Con la laparoscopia se obtienen mejores resultados estéticos y la reincorporación a las actividades normales se da en menor tiempo, lo que se traduce en menos días de incapacidad laboral

Asunto(s)

RESUMEN

Between August 1988 and October 1993, 19 patients with native aortic coarctation were subjected to transluminal percutaneous balloon angioplasty, 12 of which were men (63.1%) and 7 were women (36.9%), with an average age of 22 +/- 7.7 years (r- 16 to 52), all of whom suffered from arterial hypertension at the time of the procedure, and a systolic pressure of 190 +/- 32.2 mmHg (r- 160 to 240). The gradient of the systolic pressure (GPS) was 77 +/- 0.9 mm, the average diameter of the balloon catheters that were used was 18.3 +/- 1.7 mm (r- 15 to 20). For all the patients, the procedure was carried out under local anesthesia and the usual Seldinger technique. After carrying out the procedure, the GPS as well as the blood pressure dropped to 5.0 +/- 4.1 mmHg and 130 +/- 20.6 mmHg, respectively. In similar manner, the enlargement of the ring displayed an increase of 4.2 +/- 0.9 to 14.1 +/- 1.6 mm. There were no complications in any of the procedures. During the follow-up, 11 patients were catheterized again in a period of 24.7 +/- 12.6 months (r- 10 to 48) with GPS of 5 +/- 2 mmHg. Besides, an increase of 15.4 +/- 1.2 mm in the ring's diameter was observed. In these patients, there was no evidence of the aneurysms at the dilatation site. Of the rest of the patients under control, 17 of whom have been able to maintain normal blood pressure without medical treatment, and only two required low dosages of antihypertensive treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Asunto(s)

RESUMEN

Four monoclonal antibodies were applied, using an immunoenzymatic technique, the alkaline phosphatase anti-alkaline phosphatase, in granulopoietic cultures in vitro. In this manner, granulopoietic growth at tenth day of culture has been defined as positive for myeloid markers (CD15, CD11b) and negative for macrophagic (CD68) and proliferating cells (Ki 67) markers.

Asunto(s)

RESUMEN

UNLABELLED: From Jan-21-91 to Jan-8-92 we performed percutaneous transvenous mitral commissurotomy (PTCM) with a Medi-tech balloon catheter (MBC) in 41 patients bearing mitral stenosis simple o predominant. We utilized an anterograde transseptal approach in order to access the mitral valve, the procedure failed in 5 patients, in 30 of them we used double MBC and single MBC were utilized in 6 patients. Both left ventriculogram and hemodynamic parameters were taken before and after PTCM. Posterior to PTCM an important decrease appeared in the mitral transvalvular gradient from 20.6 +/- 2.7 to 2.4 +/- 1.7 mmHg (p < 0.0001) and an average pressure of pulmonary artery of 46.2 +/- 9.8 to 23.9 +/- 6 mmHg (p < 0.0001), and also the pulmonary arterial resistance from 1178.1 to 557.1 dinas/cm-5/seg. There was an important concomitant increase in mitral valvular area from 0.84 +/- 0.11 to 2.38 +/- 0.08 cm2 (p < 0.0001) and in cardiac rate from 2.7 +/- 0.7 to 2.9 +/- 0.52 L/min (p < 0.001). COMPLICATIONS: Two female patients developed cardiac tamponade, one of them the procedure was successful, and for the other it was decided to submit her to valvular replacement. Mitral insufficiency was present in three patients; GI/IV in two of them and GII/IV angiographic in one. Another patient presented cerebral thromboembolism with complete recovery within 15 days. Short left to right shunt was detected only in 8 patients being 1.2/1 in 6 of them, 1.3/1 in one and 1.4/1 in other patient. Thirty three uncomplicated were dismissed within a maximum of 48 hours after procedure.(ABSTRACT TRUNCATED AT 250 WORDS)

Asunto(s)

Asunto(s)

RESUMEN

Serum ferritin and haemoglobin rate were assessed in 637 men and 285 women, all of them seemingly healthy, who were about to donate blood for the first time. Serum ferritin rates suggesting iron deficiency were found in 1.88% of the men and in 9.47% of the women, anaemia being present in 7.69% of the iron deficiencies. Serum ferritin can be a useful parameter for the detection of latent iron deficiency in blood donors, and it may disclose the group of donors who should receive iron therapy, or should be recommended not to donate blood, without any significant increase on the cost per unit of blood.

Asunto(s)

RESUMEN

The interrelationship between factor XII deficiency (Hageman trait) and thrombosis is well known. A case of moderate factor XII deficiency (activity, 30%) associated to deep vein thrombosis, which occurred in the popliteal region of the left lower limb after abdominal surgery, is reported. The deficit was found in 4 family members of the three generations studied, and all of them showed a close interrelationship between factor XII activity and kallikrein levels. Prolonged APTT was found in 3 of the 4 affected subjects. A multiallelic model is suggested to explain the genetic transmission of this impairment.

Asunto(s)

Asunto(s)