RESUMEN
Lipopolysaccharideinduced (LPS) neuroinflammation serves an important role in the development of depression. Monocyte chemotactic protein1induced protein 1 (MCPIP1, also known as ZC3H12A and Regnase1) possesses endoribonuclease and deubiquitinase activities. In the present study, the effects of MCPIP1 on LPSinduced depression were assessed. A mouse model of hippocampal neuroinflammation was established by intraperitoneal injection of LPS. Microglia were treated with LPS, MCPIP1 overexpression vector, MCPIP1 knockdown vector or TLR4 inhibitor. MCPIP1 alleviated LPSinduced depressivelike behaviors. MCPIP1 facilitated M2 polarization of microglia. MCPIP1 attenuated the inflammatory response in microglia via inhibition of the TLR4/TNF receptor associated factor 6 (TRAF6)/NFκB signaling pathway. The results indicated that MCPIP1 accelerated M2polarization of microglia and alleviated depressivelike behaviors of mice via the inhibition of the TLR4/TRAF6/NFκB signaling pathway.