RESUMEN
Nonspecific phacogenic uveitis (NPGU) was simulated in 21 chinchilla rabbits to follow the time course of the blood serum proteolytic activity and the principal protease inhibitors (alpha 1 inhibitor and alpha 2 macroglobulin) in various stages of the inflammatory process. Effects of contrykal, a synthetic protease inhibitor, on these parameters and the course of the inflammation was also under study. The results evidence that i.v. and subconjunctival contrykal administration reduced the periods of NPGU treatment 1.5-2 times.
Asunto(s)
Aprotinina/uso terapéutico , Lesiones de la Cornea , Modelos Animales de Enfermedad , Lesiones Oculares Penetrantes/complicaciones , Inhibidores de Proteasas/uso terapéutico , Uveítis/tratamiento farmacológico , Animales , Activación Enzimática/efectos de los fármacos , Activación Enzimática/fisiología , Lesiones Oculares Penetrantes/enzimología , Cristalino/enzimología , Conejos , Uveítis/enzimología , Uveítis/etiología , alfa 1-Antitripsina/metabolismoAsunto(s)
Modelos Animales de Enfermedad , Obstrucción Intestinal/enzimología , Intestino Delgado/enzimología , Péptido Hidrolasas/metabolismo , Inhibidores de Tripsina/metabolismo , Enfermedad Aguda , Animales , Femenino , Obstrucción Intestinal/patología , Intestino Delgado/patología , L-Lactato Deshidrogenasa/metabolismo , Masculino , Necrosis , Ratas , Ratas Endogámicas , Succinato Deshidrogenasa/metabolismoRESUMEN
The morphofunctional state of the small intestine was studied on a tourniquet shock model. The development of postischemic toxemia is followed by disorders of microcirculation leading to irreversible changes in the small intestine. The processes are associated with an increase of the proteolytic activity of the intestinal contents. An oral administration of andecaline prevents ischemia of the intestine, contributes to the preservation of its mucosa.
Asunto(s)
Intestino Delgado/irrigación sanguínea , Isquemia/complicaciones , Calicreínas/uso terapéutico , Páncreas/enzimología , Toxemia/tratamiento farmacológico , Animales , Combinación de Medicamentos/uso terapéutico , Isquemia/prevención & control , Microcirculación/efectos de los fármacos , Extractos Pancreáticos/uso terapéutico , Povidona/uso terapéutico , Ratas , Ratas Endogámicas , Toxemia/etiologíaAsunto(s)
Intoxicación , Terminología como Asunto , Toxemia , Infecciones Bacterianas , Niño , Humanos , U.R.S.S. , VirosisRESUMEN
It was shown that alpha 2-macroglobulin (50 mg/kg, 30 min before revascularization of previously ischemized extremities) significantly inhibits the blood serum proteolytic activity and exerts similarly to contrykal (10,000 U/kg) the correcting effect on the level of arterial blood pressure and parameters of the blood flow in the kidneys, intestine and previously ischemized extremities.
Asunto(s)
Péptido Hidrolasas/sangre , Choque/tratamiento farmacológico , alfa-Macroglobulinas/uso terapéutico , Animales , Aprotinina/uso terapéutico , Gatos , Evaluación Preclínica de Medicamentos , Miembro Posterior/irrigación sanguínea , Intestinos/irrigación sanguínea , Isquemia/tratamiento farmacológico , Isquemia/enzimología , Isquemia/fisiopatología , Riñón/irrigación sanguínea , Masculino , Ratas , Ratas Endogámicas , Flujo Sanguíneo Regional/efectos de los fármacos , Choque/enzimología , Choque/fisiopatología , Factores de Tiempo , TorniquetesRESUMEN
It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.
Asunto(s)
Aprotinina/uso terapéutico , Enfermedad Coronaria/tratamiento farmacológico , Péptido Hidrolasas/sangre , Toxemia/tratamiento farmacológico , Animales , Enfermedad Coronaria/complicaciones , Enfermedad Coronaria/enzimología , Evaluación Preclínica de Medicamentos , Masculino , Ratas , Ratas Endogámicas , Factores de Tiempo , Torniquetes/efectos adversos , Toxemia/enzimología , Toxemia/etiologíaRESUMEN
It was shown on Wistar rats that trypsin and kallikrein decrease the activity of lactate dehydrogenase, alpha-glycerophosphate dehydrogenase, glycogen content and increase the activity of succinate dehydrogenase in neutrophils.