RESUMEN

Wistar rats were administered increasing doses of Russell's viper venom (RVV; 0.025-0.4 mg/kg) intraperitoneally to investigate acute kidney injury (AKI) by measuring creatinine (1.5-fold increase in serum creatinine above baseline) and examining kidney histology. Approximately 50% of rats receiving 0.25-0.4 mg/kg venom died within 72 h. An increase in serum creatinine only occurred at a venom dose of 0.4 mg/kg, except in two rats. Acute tubular necrosis, glomerular necrosis, cortical necrosis and interstitial inflammation were observed at venom doses of ≥0.25 mg/kg in 12/36 rats. However, of those 12 rats only four survived to 48 h compared to the 24 rats not developing nephrotoxicity, in which 18 were alive at 48 h. There was poor correlation between histological nephrotoxicity and AKI based on creatinine measurement. The early death in rats with AKI makes this a poor model for studying RVV-induced AKI.

Asunto(s)

Lesión Renal Aguda/inducido químicamente , Daboia , Venenos de Víboras/toxicidad , Lesión Renal Aguda/mortalidad , Lesión Renal Aguda/patología , Animales , Creatinina/sangre , Relación Dosis-Respuesta a Droga , Necrosis de la Corteza Renal , Masculino , Ratas Wistar

RESUMEN

Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC), which has a better prognosis, is seen mostly in the setting of familial adenomatous polyposis (FAP). The cytomorphology of CMV-PTC is diverse; hence, it could be mistaken for other thyroid neoplasms with bad prognostic outcome. This case is of a 24-year-old female diagnosed with polyposis coli found to have thyroid nodules at screening ultrasonography. Aspirated thyroid smears were hypercellular with epithelial cells arranged in monolayer sheets, papillae with discohesion, and spindling of cells at the edges, cribriform clusters, and cell morules. Individual cell morphology ranged from polygonal, tall columnar to spindle cells. Nuclei were round-to-oval with coarse chromatin, indistinct nucleoli, and mitotic figures. Nuclear inclusions and grooves were rare and colloid was sparse. Cytomorphology was suspicious, however, was not classical of CMV-PTC documented so far. Subsequent histology confirmed a CMV-PTC.