Asunto(s)
Endoftalmitis/diagnóstico , Dolor Ocular/microbiología , Infecciones Neumocócicas/diagnóstico , Streptococcus pneumoniae , Adolescente , Antibacterianos/uso terapéutico , Diagnóstico Diferencial , Quimioterapia Combinada , Endoftalmitis/tratamiento farmacológico , Endoftalmitis/cirugía , Femenino , Humanos , Infecciones Neumocócicas/tratamiento farmacológico , Infecciones Neumocócicas/cirugía , VitrectomíaRESUMEN
The main objective of the study was to quantify serum levels of nicotinamide phosphoribosyltransferase (Nampt/pre-B-Cell colony-enhancing factor 1/visfatin) in subjects with a history of retinal vascular occlusions (RVOs), disease conditions characterized by pronounced ischemia, and metabolic energy deficits. A case-control study of 18 subjects with a history of RVO as well as six healthy volunteers is presented. Serum Nampt levels were quantified using a commercially available enzyme-linked immunosorbent assay kit. Serum Nampt levels were 79% lower in patients with a history of RVO compared with that in healthy volunteers (P<0.05). There was no statistically significant difference among the types of RVOs, specifically branch retinal vein occlusions (n=7), central retinal vein occlusions (n=5), hemiretinal vein occlusions (n=3), and central retinal artery occlusions (n=3; P=0.69). Further studies are needed to establish the temporal kinetics of Nampt expression and to determine whether Nampt may represent a novel biomarker to identify at-risk populations, or whether it is a druggable target with the potential to ameliorate the long-term complications associated with the condition, ie, macular edema, macular ischemia, neovascularization, and permanent loss of vision.
RESUMEN
We report a case of a blinding, perforating globe injury from Taser trauma. There have been other instances involving similar circumstances, but this traumatic event resulted in the loss of all meaningful vision and eventual enucleation. Despite meticulous planning and intervention, however, Taser trauma can result in devastating ocular injury.
Asunto(s)
Segmento Anterior del Ojo/lesiones , Ceguera/etiología , Electrochoque/instrumentación , Cuerpos Extraños en el Ojo/etiología , Lesiones Oculares Penetrantes/etiología , Esclerótica/lesiones , Adulto , Segmento Anterior del Ojo/diagnóstico por imagen , Ceguera/diagnóstico , Electrochoque/efectos adversos , Enucleación del Ojo , Cuerpos Extraños en el Ojo/diagnóstico por imagen , Cuerpos Extraños en el Ojo/cirugía , Lesiones Oculares Penetrantes/diagnóstico por imagen , Lesiones Oculares Penetrantes/cirugía , Humanos , Masculino , Esclerótica/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
A 47-year-old healthy male presented to the ophthalmology clinic with complaint of dry eyes. Examination revealed visual acuity 20/20 in both eyes (OU). Anterior segment examination was normal. Fundus examination and fluorescein angiogram findings were consistent with a non-ruptured macroaneurysm. Spectral domain (SD) optical coherence tomography (OCT) (Ophthalmic Technologies, Ontario, Canada) demonstrated a large 215 mu lumen with inferior hyperreflectivity at the area of hemorrhage. There was focal thickening of the retina to encompass the macroaneurysm but no associated retinal edema. The higher resolution afforded by SD OCT may allow more accurate measurement of the size of the aneurysm, making it possible to evaluate prognostically relevant characteristics of the aneurysm such as hemorrhage in the vessel wall or thrombus in the lumen. This may also allow us to possibly intervene earlier in high-risk cases. SD OCT may be of value in management of retinal macroaneurysm.
RESUMEN
Endophthalmitis is a rare but potentially devastating complication following intraocular surgery. Endophthalmitis following intraocular surgery in children often has a poor outcome. We report a case of endophthalmitis after cataract extraction in a 6-year-old girl with a good visual result.