RESUMEN
Pluronic F 108 added to serum in a concentration of 1 g/dl proved as the optimal means to increase the fat emulgatory capacity. Similar concentrations were achieved in living rabbits by infusing 4.5 g per kg body weight. In spite of this higher dosage we failed to mobilize 131 J labelled fat, embolized into the lungs of the animals. It is concluded that also in humans there exists no possibility to mobilize fat emboli from the lungs by the application of tensides (non-ionic detergents, lecithin-preparations, bile salts) or of organic solvents (alcohol, ether). All these agents are capable to emulsify fat in vitro, however, only under vigorous shaking.--Because of the side effects of those agents their application on patients, suffering from posttraumatic fat embolism seems not to be justified.
Asunto(s)
Embolia Grasa/tratamiento farmacológico , Poloxaleno/uso terapéutico , Polietilenglicoles/uso terapéutico , Animales , Detergentes/sangre , Detergentes/uso terapéutico , Embolia Grasa/etiología , Femenino , Pulmón/fisiopatología , Enfermedades Pulmonares/tratamiento farmacológico , Masculino , ConejosRESUMEN
Various surfactants such as Pluronic L 61, L 64, F 68 and F 108, Tween 80 und Triton WR 1339 as well as bile acids and sodium taurocholate were tested for their capacity to reduce the interface tension against neutral lipids and for their capacity to induce stable emulsions of triglycerides in rabbit sera. No positive correlation was found to exist between the interface activity against neutral lipids and the lipid emulsifying capacity of rabbit sera, added with the surfactants. When ether was added to serum, the lipid emulsifying capacity was increased most at concentrations of about 0,0075 g ether per 100 ml serum. This is about 1/10 of the ether concentration, achieved during anesthesia at the stage of tolerance. Pluronic F 108 in non toxic concentrations was the agent increasing the lipid emulsifying capacity of rabbit (and human) sera most efficiently. It proved superior also to ethanol and ether and appears to be the most suitable agent for mobilization of embolized fat in lung vessels.
Asunto(s)
Embolia Grasa/fisiopatología , Lípidos/fisiología , Polietilenglicoles/farmacología , Tensoactivos/farmacología , Animales , Ácidos y Sales Biliares/farmacología , Emulsiones , Técnicas In Vitro , Polisorbatos/farmacología , Conejos , Tensión Superficial , Ácido Taurocólico/farmacología , Triglicéridos/fisiologíaRESUMEN
The damaging action on vascular endothelia of meglumin iothalamate and of meglumin ioxitalamate was tested on the rat aorta. Ioxitalamate was significantly better tolerated than iothalamate. The octanol-water-partition coefficient of various contrast media was evaluated by assessing the iodine content of the octanol phase after mixing. The coefficients found were about 100 fold lower than the coefficients computed by Levitan and Rapoport. The significance of the octanol-water-partition coefficient for endothelial injuries caused by contrast media is disputed.