RESUMEN

The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta, Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhibitory concentration 50 (IC50) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC50 between 41 microM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet.

Asunto(s)

Extractos Vegetales/farmacología , Plantas Medicinales , Tripanocidas/farmacología , Trypanosoma cruzi/efectos de los fármacos , Animales , Chlorocebus aethiops , Células HeLa/efectos de los fármacos , Humanos , Macrófagos/efectos de los fármacos , Extractos Vegetales/química , Trypanosoma cruzi/citología , Células Vero/efectos de los fármacos