RESUMEN
The possibility of using sodium nucleinate for the treatment of acute dysentery has been confirmed in experiments on guinea pigs with the use of the keratoconjunctival test as an experimental model. The capacity of sodium nucleinate to enhance the antibiotic sensitivity of shigellae isolated from infected eyes to kanamycin, tetracycline and chloramphenicol has been established. The effect produced by individual ribonucleotides contained in sodium nucleinate have been studied and found to be differently directed.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Disentería Bacilar/tratamiento farmacológico , Queratoconjuntivitis/tratamiento farmacológico , Ácidos Nucleicos/uso terapéutico , Ribonucleótidos/uso terapéutico , Shigella flexneri , Animales , Modelos Animales de Enfermedad , Evaluación Preclínica de Medicamentos , Quimioterapia Combinada , Cobayas , Inducción de Remisión , Factores de TiempoRESUMEN
Experiments on animals and clinical observations over patients with infectious-allergic bronchial asthma and rheumatism showed that sodium nucleinate could abolish or suppress the intensity of immediate and delayed type hypersensitivity and the corresponding skin reactions to specific allergens.